Amoxiclav Powder

What is Amoxiclav?

Amoxiclav Powder is the raw material for amoxicillin-clavulanate potassium powder. It is a compound antibacterial active pharmaceutical ingredient composed of amoxicillin and clavulanate potassium in a scientific ratio. It appears as a white to off-white powder and belongs to the broad-spectrum β-lactam compound raw material class. Clavulanate potassium can inhibit the β-lactamase produced by bacteria, protect amoxicillin from being destroyed, and greatly enhance the antibacterial effect.

What are the effects of Amoxiclav?

The core function of Amoxiclav Powder lies in three aspects: broad-spectrum antibacterial activity, overcoming drug resistance, and synergistic effects. First, its amoxicillin component exhibits definite bactericidal activity against a variety of Gram-positive and Gram-negative bacteria, effectively inhibiting bacterial cell wall synthesis and leading to bacterial lysis and death. Second, clavulanic acid, as an irreversible β-lactamase inhibitor, binds tightly to and inactivates the β-lactamases secreted by enzyme-producing resistant bacteria, thus protecting amoxicillin from degradation and restoring its sensitivity to resistant strains.It is this synergistic combination of "antibiotic + enzyme inhibitor" that allows Amoxiclav Powder to effectively cover mixed infections caused by β-lactamase-producing resistant bacteria without the need for additional antibiotics. Clinically, this product is effective against various bacterial infections in adults and children, particularly in the treatment of otitis media, sinusitis, lower respiratory tract infections, and complicated urinary tract infections, significantly alleviating symptoms and shortening the course of illness.

Where is Co-Amoxiclav used?

Amoxiclav powder is primarily used in the treatment of infections, specifically targeting bacterial infections in multiple sites including the respiratory, genitourinary, skin and soft tissue, bone and joint, and abdominal cavities. In the respiratory system, it can treat common infections such as acute bacterial sinusitis, acute otitis media, acute exacerbations of chronic bronchitis, community-acquired pneumonia, tonsillitis, and pharyngitis. In the genitourinary system, it is suitable for infections such as cystitis, pyelonephritis, urethritis, and pelvic inflammatory disease.

In skin and soft tissue infections, it is effective in treating cellulitis, animal bites, diabetic foot infections, and severe odontogenic abscesses with cellulitis. Furthermore, Co-Amoxiclav can be used to treat bone and joint infections such as osteomyelitis, as well as severe systemic infections such as abdominal infections and sepsis, and can also be used for the prevention of postoperative infections. In pharmaceutical manufacturing, Amoxiclav powder is a core raw material for the preparation of various oral suspensions, dry suspensions, injectable powders, and generic drugs.

MF of Amoxiclav

Molecular Formula: C16​H19N3O5S⋅C8H9NO5
Molecular Weight: 494.46
Exact Mass: 494.1104
Melting Point: 194°C
Boiling Point: 701.8±70.0 °C
Density: 1.6±0.1 g/cm³
Flash Point: 378.2±35.7 °C

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Product Specification

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FAQ：

Q1: What are the advantages of Amoxiclav's compound formulation and antibacterial properties?

A1: It is produced strictly according to pharmacopoeia standards, with a precise ratio of amoxicillin to potassium clavulanate, resulting in stable synergistic antibacterial effects. It effectively combats enzyme-producing drug-resistant strains. The raw materials are of high purity, and the content of active ingredients meets standards. The antibacterial activity is highly consistent across batches, making it suitable for the production needs of various anti-infective preparations.

Q2: What are the core advantages of Amoxiclav's physicochemical quality?

A2: The raw material is a uniform and fine powder with good flowability and is not prone to clumping. Moisture, related substances, and heavy metals are strictly controlled. It has stable crystal form and is not easily degraded or deteriorated. It is suitable for various formulation processes such as tablets, granules, and dry suspensions, ensuring the stability of downstream drug production.

Q3: Does Amoxiclav meet the compliance requirements for domestic and international applications?

A3: The supply comes from GMP-certified factories, complying with BP/USP/EP standards. Each batch comes with a complete COA and MSDS, supporting third-party testing. It can be used for domestic and international drug registration applications and generic drug consistency evaluations. The supply is stable and meets export compliance requirements.

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