Guanfacine Hydrochloride API CAS 29110-48-3
Product Name:Guanfacine hydrochloride API
CAS.no:29110-48-3
molecular formula:C9H9Cl2N3O.ClH
EINECS.NO:249-443-3
Synonym:GUANFACINE HCL;estulic;bs100-141;lon798;n-(aminoiminomethyl)-2,6-dichloro-benzeneacetamidmonohydrochloride
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
What is GUANFACINE HCL?
Guanfacine hydrochloride is a white powder and an antihypertensive product. It has a certain effect on hypertension and is a centrally acting α2A-adrenergic receptor agonist. Guanfacine hydrochloride API lowers blood pressure by activating central α2 receptors and reducing peripheral sympathetic nerve activity. Currently, its main use is to treat attention deficit hyperactivity disorder in children and adolescents aged 6 to 17. This product has a relatively long half-life, and its effects may last for a period of time. However, some side effects may occur during use, such as drowsiness, feelings of dehydration, or lethargy. Treatment should not be interrupted abruptly, and sudden, significant increases in blood pressure should be avoided. Furthermore, safety data for pregnant women, breastfeeding women, and young children are still insufficient; therefore, caution must be exercised when using it.
contact us by Email ：sales6@faithfulbio.com
How does GUANFACINE HCL reduce voltage?
This product is very similar to CLONIDINE, but its sedative effect is weaker, resulting in fewer side effects. After crossing the blood-brain barrier, Guanfacine hydrochloride API stimulates α2A receptors in the nucleus tractus solitarius and locus coeruleus of the medulla oblongata, thereby reducing the output of sympathetic nerve impulses. Furthermore, it slows the heart rate, weakens myocardial contractility, and reduces the amount of blood pumped by the heart, resulting in a dual blood pressure-lowering effect.
Moreover, this product lowers blood pressure through central regulation and does not directly affect blood vessels or kidneys; therefore, long-term use will not cause reflex tachycardia.
Why does abruptly discontinuing GUANFACINE HCL lead to a tendency for blood pressure to rebound?
The rebound in blood pressure after abruptly stopping GUANFACINE HCL is primarily due to the sudden release of the central sympathetic nervous system, which was previously suppressed by the product, leading to an overcompensatory reaction in the body. Guanfacine hydrochloride API acts on α2A receptors in the brainstem, suppressing the release of sympathetic nerve signals, slowing the heart rate, regulating vascular resistance, and stabilizing blood pressure. Abruptly stopping use causes the receptors to lose certain activation, resulting in a faster heart rate, sudden vasoconstriction, and a rapid rise in blood pressure. In some individuals, this can lead to even higher blood pressure than before, and in extreme cases, may trigger a hypertensive emergency. Therefore, it is crucial to discontinue use gradually, not abruptly.
MF of GUANFACINE HCL
| CAS | 29110-48-3 |
| Molecular formula | C9H9Cl2N3O.ClH |
| Molecular weight | 282.55 |
| EINECS | 249-443-3 |
| Melting point | 215-217℃ |
| Stability | Hygroscopicity |
| Solubility | H2O: 12 mg/mL,60 °C |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Odor & Tasted | Characteristic | Complies |
| Assay(%) | ≥98.0 | 98.65 |
| Loss on Drying(%) | ≤0.5 | 0.14 |
| Residue on Ignition(%) | ≤0.1 | 0.02 |
| Heavy Metal(ppm) | ≤10.0 | Complies |
| Pb(ppm) | ≤1.0 | Complies |
| As(ppm) | ≤1.0 | Complies |
| Hg(ppm) | ≤0.1 | Complies |
| Cd(ppm) | ≤1.0 | Complies |
| Conclusion | Conform with enterprise specification | |
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Guanfacine hydrochloride API etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1: What are our markets?
With superior quality and competitive price, our products not only are sold well in China, but also exported to Europe, North America, Southeast Asia, the Middle East and South Africa.
Q2: If I don't know how to use product, can you give me an instruction?
Yes, you can send email to get product label and instruction. We have professional agricultural expert working in our company and supply the application information and offer solving solution.
Q3:Can I get free sample?
If you're manufacturer or distributor in the same field with us. Welcome to request a sample. Sample is free, but express freight will be in your account. When you place order in the future, previous sample and express freight will be deducted from the cost of the order.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
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