What is GlyT2-IN-1?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. GlyT2-IN-1, also commonly known as Yoda-1, is a thiadiazole small-molecule research compound with a molecular weight of 355.27. This substance appears as a solid powder. Its core scientific value lies in its activation of the Piezo1 mechanosensitive ion channel, regulating its opening state, slowing down its inactivation process, and promoting calcium ion influx into the cell, thereby mimicking the signal transduction process (PMC) after mechanical stimulation.
Application of GlyT2-IN-1
GlyT2-IN-1 is a commonly used tool molecule in the field of mechanobiology and is widely used in research on cell mechanical signal transduction. It can be used to explore various cellular physiological processes such as the response of vascular endothelial cells to fluid shear forces, cell migration, differentiation of bone-related cells, and morphological changes of erythrocytes. It is also compatible with various in vitro experimental modes such as cell incubation, electrophysiological recording, and fluorescence imaging.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white solid | White powder |
| Identification(1H-NMR) | Consistent with structure | Conforms |
| Identification(LC-MS) | Molecular ion peak consistent | Conforms |
| Identification(HPLC Rt) | Rt matches reference standard | Conforms |
| Purity(HPLC) | ≥98.0% | 99.2% |
| Melting Point | Report | 178-181℃ |
| Water Content(KF) | ≤1.0% | 0.3% |
| Residual Solvent | Within ICH limits | Conforms |
| Heavy Metals | ≤20 ppm | <20 ppm |
| Assay(By weight,on dried basis) | 98.0%-102.0% | 99.1% |
| Conclusion | Conform with enterprise specification | |
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Density 1.58±0.1 g/cm3 (Predicted)
Boiling Point 538.4±60.0 °C (Predicted)
Molecular Formula C13H8Cl2N4S2
Molecular Weight 355.27
Flash Point 279.4±32.9 °C
Exact Mass 353.956757
LogP 4.89
InChIKey BQNXBSYSQXSXPT-UHFFFAOYSA-N
Mechanism of action of GlyT2-IN-1
This compound is capable of attaching to the Piezo1 mechanosensitive ion channel and heightening the channel's responsiveness toward mechanical cues.
GlyT2-IN-1 slows down the inactivation of Piezo1 channels and keeps the channels open for longer periods.
Once Piezo1 channels become activated, they facilitate calcium ion flow across the cell membrane into the cytoplasm, which raises intracellular calcium signal intensity.
Elevated calcium signals inside the cell trigger a series of downstream signaling cascades, which in turn govern cytoskeleton reorganization.
Even in the absence of physical mechanical input, this agent reproduces channel activation triggered by mechanical stress, generating mechanosignal responses through chemical means.
Early research noted an interaction between this agent and glycine transporter 2; nevertheless, later investigations demonstrate that this is not its principal target of action.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What are the storage conditions for GlyT2-IN-1?
The solid powder is recommended to be stored at -20°C in a sealed container, protected from light; avoid repeated freeze-thaw cycles.
02. Early literature mentioned GlyT2 as a target; is this its main focus?
No, while there were some early annotations, subsequent extensive research has shown that regulating the Piezo1 channel is the main research direction for this compound.
03. What experimental methods outside of biological organisms can GlyT2-IN-1 be used for?
GlyT2-IN-1 is compatible with various in vitro laboratory research methods, including calcium fluorescence imaging, patch-clamp electrophysiology, and in vitro cell incubation.
Click email：Sales4@Faithfulbio.Com Or WhatsApp：+86 17782784907
Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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