Overview of Etodolac：
Etodolac powder also known as indomethacin, indolopyranoacetic acid, Lodine, etc., is a new generation of COX-2 highly selective non-steroidal anti-inflammatory drugs. This product is a weakly acidic drug, and it is in molecular form at a low pH value, which is beneficial to the absorption of the drug. Etodolac powder is widely used in the treatment of postoperative pain in clinic.Etodolac is a white crystalline powder with melting point of 145 ~ 148℃.
| Product name | Etodolac |
| CAS | 41340-25-4 |
| Molecular formula | C17H21NO3 |
| Molecular weight | 287.35 |
| EINECS Number | 629-689-1 |
| Melting point | 145-1480C |
| boiling point | 507.9±45.0 °C(Predicted) |
| Solubility | Almost insoluble in water, but soluble in acetone and ethanol (96%) |
| Appearance | White or off-white solid powder |
| Storage condition | 2-8°C |
| Density | 1.193±0.06 g/cm3(Predicted) |
What is the pharmacological action of Etodolac ?
This product is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects. Its mechanism may be that it inhibits the synthesis of prostaglandin (PG) by blocking the activity of cyclooxygenase.
Etodolac has analgesic and anti-inflammatory effects.
etodolac is a non-steroidal anti-inflammatory drug. As an analgesic and anti-inflammatory drug, its efficacy can be compared with aspirin, other analgesics and many commonly used prescriptions at present. Etodolac powder selectively inhibits prostaglandin biosynthesis in inflammatory sites, and the inhibition of gastric prostaglandin is slight and short-lived when given to rats with therapeutic dose. This may be the mechanism of less gastrointestinal adverse reactions.
Etodolac can reduce the incidence and severity of bone and joint damage
The adjuvant arthritis model in rats showed that etodolac could reduce the incidence and severity of bone and joint injuries and reverse the disease progress. No teratogenic effect was found in animal experiments, and Etodolac powder had little effect on fertility and general reproductive function. However, animal experiments during pregnancy show that drugs that inhibit prostaglandin biosynthesis can cause dystocia and delay delivery. Some inhibitors of prostaglandin biosynthesis can interfere with the closure of arterial ducts.
Product Specification
| Item | Specification | Results | |
| Appearance | White or off-white solid powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Solubility | Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water | Complies | |
| Polymorphic Form | Polymorphic form 1 | Complies | |
| Water Content | ≤ 0.50% | 0.10% | |
| Heavy Metals | ≤ 20ppm | Complies | |
| Residue on Ignition | ≤ 0.20% | 0.09% | |
| Related Substance | Any single impurity: ≤0.10% | 0.06% | |
| Total Impurities: ≤1.00% | 0.16% | ||
| Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
| Particle Size | D90: ≤100µm | Complies | |
| Conclusion: The test results are conformed to the in-house specification | |||
What is the difference between Etodolac and ibuprofen?
1. The mechanism of action is different:
Ibuprofen is a non-selective non-steroidal anti-inflammatory drug, which inhibits both COX-1 and COX-2, while Etodolac is a selective non-steroidal anti-inflammatory drug, which only inhibits the activity of COX-2;
2. Different analgesic effects:
Ibuprofen is mainly used to relieve mild to moderate pain, while Etodolac powder. is generally used to relieve moderate to severe pain. Its analgesic effect is relatively strong, and its inhibitory effect on COX-2 is more targeted.
3, adverse reactions:
Ibuprofen is more irritating to the gastrointestinal tract, which may cause nausea and vomiting; However, Etodolac has relatively little stimulation to the gastrointestinal tract, and few gastrointestinal related adverse reactions occur.
How is etodolac synthesized?
Firstly, Etodolac was prepared, and then it was obtained by hydrolysis, acidification, organic phase crystallization and petroleum ether refining. Therefore, the industrial 7- ethyl tryptophanol and ethyl propionyl acetate can be used as raw materials to synthesize ethyl etodolate, and then the crude etodolac can be directly prepared by hydrolysis and aqueous acidification, and then the refined etodolate can be obtained by recrystallization with isopropanol-water.The above is the synthesis process of Etodolac powder.
How and where to buy Etodolac powder wholesale?
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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