What is Clarithromycin?
Clarithromycin is a derivative of erythromycin, a broad-spectrum antibiotic, which belongs to macrolide antibiotics. Clarithromycin plays an antibacterial role mainly by inhibiting the synthesis of bacterial protein, and has a good therapeutic effect on some infectious diseases.
Clarithromycin powder is white crystalline powder or colorless needle crystal, odorless and bitter. Easily soluble in chloroform, acetone or ethyl acetate, slightly soluble in ethanol, ether or methanol, almost insoluble in water. Colorless needle-like crystals were obtained from chloroform-isopropyl ether (1:2), with melting point of 217,220℃ (decomposition). Or from ethanol, melting point 222 225℃. [α](20, d)-90.4, (c = l, chloroform). UV maximum absorption (chloroform); 288nm(e27. 9).
Clarithromycin has antibacterial activity, which is effective against Gram-positive bacteria and negative bacteria, and also has inhibitory effect on many penicillin-sensitive strains.
| Product name | Clarithromycin |
| CAS | 81103-11-9 |
| Molecular formula | C38H69NO13 |
| Molecular weight | 747.95 |
| EINECS Number | 1806241-263-5 |
| Storage condition | -20°C |
| Melting point | 217-220°C |
| Solubility | Soluble in dimethyl sulfoxide |
| Appearance |
White powder |
| Boiling point | 86℃ |
| Flash(ing) point | 1.1334 (rough estimate) |
What is the pharmacological action of clarithromycin?
Clarithromycin is a broad-spectrum antibiotic of 14 yuan macrolide. Its mechanism of action is the same as erythromycin, which mainly binds to bacterial 50S ribosome subunit, and inhibits the synthesis of bacterial protein by blocking peptide transfer and mRNA translocation, thus playing an antibacterial role. Compared with erythromycin powder, clarithromycin powder has the characteristics of good absorption, fast peak time, high blood concentration, long half-life and small individual difference. Clarithromycin has a slightly stronger antibacterial effect on methicillin-sensitive Staphylococcus and Streptococcus than erythromycin. The antibacterial activity against influenza Bacillus is 2 ~ 4 times stronger than erythromycin. Clarithromycin has bacteriostatic effect on Staphylococcus aureus and Streptococcus. It has bactericidal effect on pneumococcus and influenza Bacillus. Drug-resistant bacteria can produce an enzyme that methylates RNA and methylates the binding site of ribosomes, thus making drugs unable to bind to ribosomes. In vivo antibacterial test, the antibacterial effect of clarithromycin on Staphylococcus aureus, Streptococcus pyogenes, Pneumococcus and Haemophilus influenzae is 2 ~ 10 times stronger than that of erythromycin.
Product Specification
| Item | Specification | Results |
| Description | White or almost white crystalline powder | Complies |
| Solubility | Practically insoluble in water, Soluble in aceto.ne | Complies |
| and in ethylene slightly soluble in metha.nol. | ||
| Identification | Conforms to claritinomycin RS | Complies |
| IR spectrum | ||
| Specific rotation | Between -89°C and -95°C | -90.0°C |
| Crystallinity | Meets the requirement | Meets the requirement |
| pH | Between 7.5and 10.0 | 8.58 |
| Water | Not more than 2.0% | 0.64% |
| Residue on ignitions | Not more than 0.3% | Complies |
| Assay | 99.00% | 99.80% |
| Conclusion | Conform USP Standard. | |
What are the uses of Clarithromycin?
1.Clarithromycin is a macrolide antibiotic, which is a derivative of erythromycin, and clarithromycin is obtained by changing the OH group on the 6th position of erythromycin A to OCH3. It is effective against gram-positive and negative bacteria, chlamydia and mycobacteria, and can effectively inhibit almost all respiratory pathogens.
2. Clarithromycin belongs to macrolide antibiotics, which are used to treat upper and lower respiratory tract infections and subcutaneous soft tissue infections.
3. Clarithromycin powder can also be used as other raw materials.
HTML5 atlas of Clarithromycin
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Where is Clarithromycin used?
1.Clarithromycin can be used to treat pharyngitis and tonsillitis caused by Streptococcus pyogenes.
2. It can be used to treat acute otitis media, acute attack of chronic bronchitis and pneumonia caused by sensitive bacteria.
3. It can be used to treat skin and soft tissue infections caused by sensitive bacteria.
4. It can be used to treat mycoplasma pneumoniae pneumonia, urethritis caused by Chlamydia trachomatis and nonspecific urethritis.
5. It can be used to treat legionnaires' disease.
6. Clarithromycin powder can also be used in combination with other drugs to treat Mycobacterium avium infection and Helicobacter pylori infection.
What's the difference between clarithromycin and azithromycin?
The differences between clarithromycin and azithromycin include different types, different efficacy and different product safety.
1. Different types:
Azithromycin is a macrolide antibiotic. Clarithromycin is a semi-synthetic macrolide antibiotic.
2, the effect is different:
Azithromycin and clarithromycin are commonly used to treat various sensitive bacterial infectious diseases. Clarithromycin has a good effect on anaerobic bacteria, while azithromycin has a good effect on chlamydia infection.
3. Different product safety:
Compared with clarithromycin, azithromycin has relatively few side effects. Azithromycin can be used for pregnant women, but clarithromycin cannot be used for pregnant women.
What is the difference between amoxicillin and clarithromycin?
Amoxicillin and clarithromycin are both antibiotics, but they are different in product classification, antibacterial spectrum, antibacterial activity, post-antibiotic effect and product interaction.
1, product classification
Amoxicillin is a penicillin antibiotic, while clarithromycin is a macrolide antibiotic.
2, antibacterial spectrum
Amoxicillin has good antibacterial activity against a variety of gram-positive bacteria and gram-negative bacteria. Clarithromycin has good antibacterial activity against a variety of gram-positive bacteria and gram-negative bacteria.
3, antibacterial activity
The antibacterial activity of amoxicillin is stronger than that of clarithromycin.
4. Post-antibiotic effect
Amoxicillin is mainly metabolized by kidney in vivo, while clarithromycin is mainly metabolized by liver in vivo, so there are some differences in post-antibiotic effects between the two products.
5, product interaction
Both amoxicillin and clarithromycin can cause gastrointestinal reactions. However, the inhibitory effect of amoxicillin on CYP3A4 is weaker than that of clarithromycin, so amoxicillin and clarithromycin generally do not need special product interaction tests.
What are the precautions of Clarithromycin powder?
1, liver function damage, moderate to severe renal function damage with caution.
2, serious damage to renal function, must make dose adjustment.
3. Clarithromycin powder is cross-allergic and cross-resistant to erythromycin and other macrolides.
4. Like other antibiotics, serious infection caused by fungi or drug-resistant bacteria may occur. At this time, it is necessary to stop using Clarithromycin and adopt appropriate treatment.
5. Hemodialysis or peritoneal dialysis can not reduce the plasma concentration of Clarithromycin.
How and where to buy Clarithromycin Powder wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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