Esomeprazole magnesium is the S form of omeprazole and a commonly used proton pump inhibitor in clinical practice, which reduces gastric acid secretion through a specific targeted mechanism of action. Pure Esomeprazole magnesium trihydrate powder is a white or off white crystalline substance that is slightly soluble in water.
|
Items |
Specifications |
Results |
|
Appearance |
white or slightly coloured powder,slightly hygroscopic |
white powder,slightly hygroscopic |
|
Identification |
A.Infraed absorption spectrophotometry Comparison:Esomeprazole magnesium trihydrate CRS B.Atomic absorption spectrometry as desicribed in test for magnesium |
Conforms Conforms |
|
Color of solution |
The absorbance is no greater than 0.2 |
0.05 |
|
Chromatographic purity |
Omeprazole N-oxide≤0.1% Omeprazole Sulfone≤0.2% Each unspecified Impurity≤0.1% Total Impurities≤0.5% |
0.02% 0.08% Conforms 0.12% |
|
Enantiomeric purity |
R-enantiomer≤0.2% |
0.08% |
|
Magnesium |
3.30%～3.55%(anhydrous substance) |
3.46% |
|
Water |
6.0%～8.0% |
6.82% |
|
Residual solvents |
Acetone:≤0.5% Methanol:≤0.3% Ethyl acetate:≤0.5% |
0.005% 0.011% 0.012% |
|
Assay |
98.0～102.0%(anhydrous substance) |
99.5% |
|
Conclusion:This product conforms with the USP35. |
||
The efficacy and function of esomeprazole magnesium enteric-coated tablets?
The active ingredient of esomeprazole magnesium enteric coated tablets is esomeprazole magnesium (trihydrate), which is an exosome inhibitor that can inhibit H+/K+- ATPase activity, thereby blocking exosome release. Clinically, it is mainly used to treat digestive system diseases such as gastric ulcers, duodenal ulcers, and reflux esophagitis caused by excessive gastric acid secretion.
|
|
|
| 161973-10-0 Esomeprazole magnesium | 217087-09-7 Esomeprazole magnesium trihydrate |
1. Applied to gastroesophageal reflux disease,Including the initiation and maintenance treatment of erosive esophagitis; This product can completely control symptoms such as acid reflux and heartburn in patients;
2. Combining appropriate antibiotics can eradicate Helicobacter pylori, such as treating duodenal ulcers caused by Helicobacter pylori infection, while also preventing the recurrence of Helicobacter pylori related gastrointestinal ulcers;
3. If critically ill patients want to prevent acute gastric mucosal lesions caused by various stress states, esomeprazole magnesium can be chosen to alleviate their pain and easily control the progression of acute gastric mucosal lesions.
It is worth noting that the use of Esomeprazole magnesium trihydrate can alleviate symptoms, mask the condition, and may potentially delay normal treatment. Therefore, before diagnosing diseases such as gastric ulcers, tumor markers and gastroscopy examinations should be perfected. Exclude issues such as gastric malignant tumors.
What is the difference between omeprazole and esomeprazole magnesium?
1.In terms of structure, omeprazole and Esomeprazole magnesium can be said to be very similar, basically identical, but customers who know chiral isomers know it. Generally, only one type of optical isomer is effective. In omeprazole, the R-type and S-type optical isomers are a 1:1 mixture. Esomeprazole magnesium is the more potent single S-isomer of omeprazole, eliminating the less effective R-isomer. This simplification results in stronger acid suppression, longer lasting efficacy, and lower side effects of the product.
2.Omeprazole enteric coated capsules are suitable for gastric ulcers, duodenal ulcers, stress ulcers, Reflux esophagitis and Zhuo-Ai syndrome (gastrinoma), but require a physician's diagnosis before use. If excessive stomach acid is caused by improper diet and you want to relieve symptoms such as heartburn and acid reflux, you can use this product on your own without obtaining a doctor's permission, but you should strictly follow the product instructions.For the routine use of Esomeprazole magnesium trihydrate, such as symptom control of GERD, please refer to the efficacy and effects section above. However, if you need to continue using nonsteroidal anti-inflammatory products to treat your illness, it is recommended to use them together with esomeprazole magnesium enteric coated tablets. Because nonsteroidal anti-inflammatory drugs such as ibuprofen, diclofenac, Indometacin etc. inhibit prostaglandin synthesis, damage the gastrointestinal mucosa, and long-term use can easily induce peptic ulcers.Our company can not only provide products related to Esomeprazole, such as Omeprazole; Esomeprazole magnesium trihydrate; We can also provide NSAID products such as ibuprofen, diclofenac, Indometacin, etc. If you have purchasing plans, please contact us via email：sales6@faithfulbio.com.
|
|
|
| 73590-58-6 Omeprazole | 119141-88-7 Esomeprazole |
|
|
|
|
| 15687-27-1 ibuprofen | 15307-86-5 diclofenac | 53-86-1 Indometacin |
Regarding the drug interactions of this product
Some drugs may interact with esomeprazole magnesium trihydrate, including prescription drugs, over-the-counter drugs, vaccines, vitamins, traditional Chinese medicine and so on. Please consult a doctor before using these drugs with esomeprazole magnesium trihydrate.
1. When combined with clarithromycin, the Area Under the Curve (AUC) of esomeprazole magnesium trihydrate is doubled, but it is not necessary to adjust its dosage.
2. The plasma concentration of phenytoin increased by 13% when patients with epilepsy combined with esomeprazole magnesium trihydrate 40 mg and phenytoin, so it is suggested to monitor the plasma concentration of phenytoin.
3. During the treatment with esomeprazole magnesium trihydrate, due to the decrease of gastric acid secretion, the absorption amount of some drugs affected by gastric acid can be changed (for example, the absorption of ketoconazole, itraconazole and iron can be reduced).
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.Our company can not only provide products related to Esomeprazole, such as Omeprazole; Esomeprazole magnesium trihydrate; We can also provide NSAID products such as ibuprofen, diclofenac, Indometacin, etc. If you are interested, please share with us.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: esomeprazole magnesium trihydrate cas 217087-09-7, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China