What is Empagliflozin?
Empagliflozin is an inhibitor of SGLT-2, Sodium-Dependent Glucocotransport ChemicalBook 2 jointly developed by Boehringer Ingelheim Company and Lilly Company. SGLT-2 inhibitor is a new hypoglycemic agent, which mainly reduces the reabsorption of glucose by kidney and increases the excretion of glucose in urine, thus reducing the plasma glucose level. Its hypoglycemic effect is independent of β cell function and insulin resistance.
Empagliflozin powder is a chemical substance, which is white or off-white powder and insoluble in water. ≥ 20.75 mg/ml in DMSO; ≥7.06 mg/mL, ethanol solution, ultrasonic wave
| Product name | Empagliflozin |
| CAS | 864070-44-0 |
| Molecular formula | C23H27ClO7 |
| Molecular weight | 450.91 |
| EINECS Number | 620-176-8 |
| Storage condition | 2-8°C |
| Boiling point | 665℃ |
| Solubility | Solubility is insoluble in water; ≥ 20.75 mg/ml in DMSO; ≥7.06 mg/mL, ethanol solution, ultrasonic wave |
| Appearance | white or off-white powder |
| Density | 1.398 |
| Flash(ing) point | 356℃ |
What is the mechanism of action of Empagliflozin?
1. Promote insulin secretion:
Empagliflozin can stimulate islet β cells to release insulin, thus increasing insulin secretion and helping to lower blood sugar.
2. Reduce glucagon levels:
Empagliflozin can inhibit the release of glucagon from islet α cells, thus reducing the level of glucagon, reducing the production and release of glucose by liver, and further reducing blood sugar.
3. Improve insulin resistance:
Empagliflozin can also improve insulin resistance, improve the sensitivity of tissues to insulin, make insulin work more effectively and lower blood sugar.
4. Protect islet β cells:
Empagliflozin can protect islet β cells from damage, maintain their normal function and help to control blood sugar for a long time.
5. Protective effect on cardiovascular system:
The study found that Empagliflozin also has the function of reducing the risk of cardiovascular disease.
Product Specification
| Item | Specification | Results |
| Appearance | Powder | Complies |
| Color | white Powder | Complies |
| Particle Size | 100% pass 80 mesh | Complies |
| Oder | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Loss on Drying | ≤5.0% | 2.20% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Residual acetone | ≤0.1% | Complies |
| Residual Ethanol | ≤0.5% | Complies |
| Heave Mentals | ≤10ppm | Complies |
| Na | ≤0.1% | <0.1% |
| Pb | ≤3 ppm | Complies |
| Total Plate | <1000CFU/g | Complies |
| Yeast & Mold | <100 CFU /g | Complies |
| E. Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| Conclusion: Conform with USP Standard | ||
What are the uses of Empagliflozin?
1. Reduce blood sugar level: Empagliflozin can reduce blood sugar level by promoting insulin secretion, promoting glycogen synthesis and inhibiting glycogen decomposition.
2. Improve insulin sensitivity: Empagliflozin can improve the sensitivity of cells to insulin, promote the uptake and utilization of glucose, and help to improve insulin resistance and metabolic disorders.
3. Antioxidant and anti-inflammatory: Empagliflozin has certain antioxidant and anti-inflammatory effects, which is helpful to reduce the inflammatory reaction and oxidative stress of diabetic patients and prevent complications.
4. Protect the cardiovascular system: Empagliflozin can protect the health of the cardiovascular system and prevent cardiovascular and cerebrovascular diseases by lowering blood sugar, improving blood lipid metabolism and reducing vascular inflammation.
In a word, Empagliflozin powder is an effective oral hypoglycemic drug, which can improve the blood sugar control and metabolic status of diabetic patients, prevent complications and improve the quality of life.
HTML5 atlas of Empagliflozin
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Dapagliflozin, Empagliflozin, Canagliflozin, Erugliflozin L-pyroglutamic acid are all SGLT2 inhibitors. What's the difference?
These products are SGLT2 inhibitors, which have the effects of reducing blood volume, reducing myocardial oxygen consumption and reducing cardiac preload, and are mainly used to treat type 2 diabetes and heart failure.
1. Dapagliflozin：Dapagliflozin is a hypoglycemic agent, and its main component is Dapagliflozin powder. It can inhibit glucose reabsorption mediated by SGLT-2, thus playing a hypoglycemic role. In addition, Dapagliflozin can inhibit the reabsorption of sodium and water by renal tubules, reduce filtration, reduce blood pressure, protect the kidney and inhibit the progress of renal vascular remodeling.
2. Empagliflozin：Empagliflozin is a new hypoglycemic agent, and its main component is Empagliflozin powder. It reduces the reabsorption of glucose by renal tubules and increases the excretion of urine glucose by inhibiting the renal SGLT2, thus achieving the effect of lowering blood sugar. In addition, Empagliflozin can also reduce the hospitalization risk of heart failure and the risk of renal failure.
3. Canagliflozin：Canagliflozin is a hypoglycemic agent, and its main component is Canagliflozin powder. It reduces the reabsorption of glucose by renal tubules and increases the excretion of urine glucose by inhibiting the renal SGLT2, thus achieving the effect of lowering blood sugar. In addition, Canagliflozin can also reduce the hospitalization risk of heart failure and the risk of renal failure.
4. ertugliflozin L-pyroglutamic acid: ertugliflozin L-pyroglutamic acid is a hypoglycemic agent, which can reduce the reabsorption of filtered glucose in kidney and increase urine glucose excretion, and is used to treat type 2 diabetes. Ertigliflozin L-Pyroglutamic acid powder is a hypoglycemic agent, which can reduce the reabsorption of filtered glucose in kidney and increase urine glucose excretion, and is used to treat type 2 diabetes.
Dapagliflozin, Empagliflozin, Canagliflozin and Erugliflozin L-pyroglutamic acid are all SGLT2 inhibitors, which have the functions of lowering blood sugar and protecting kidney. However, there may be differences in specific drug components, mechanism of action, indications and adverse reactions. When using these drugs, you should follow the doctor's advice and prescription, and choose according to your personal illness and physical condition.
Is Empagliflozin an SGLT2 inhibitor?
Empagliflozin is an inhibitor of SGLT2, which is a kind of hypoglycemic drug.
Engleggin powder is an SGLT2 inhibitor, which can be used to treat type 2 diabetes by reducing the glucose reabsorption in the kidney, lowering the renal glucose threshold and promoting the excretion of glucose from urine.
What are the precautions of Empagliflozin?
1. Severe allergic reaction: If you have ever had an allergic reaction to Empagliflozin, you should not use Empagliflozin.
2. Renal insufficiency: If patients have problems with renal function, especially severe renal injury with an anhydride clearance rate of less than 30 ml per minute, or patients with end-stage renal disease, and patients who need dialysis, Empagliflozin should be avoided.
3. Ketoacidosis: If the patient has symptoms of suspected ketoacidosis, the use of Empagliflozin should be suspended.
4. Type 1 diabetes: Patients with type 1 diabetes should not use Empagliflozin.
5. Decreased food intake or loss of body fluids: If the patient has decreased food intake or lost a lot of body fluids during the use of Empagliflozin, the use of Empagliflozin should be suspended.
6. Urogenital infection: If the patient has urogenital infection during the use of Empagliflozin, the use of Empagliflozin should be suspended.
7. Elevated low-density lipoprotein: If the patient's low-density lipoprotein is significantly elevated, Empagliflozin should also be avoided.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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