Cisatracurium besylate powder is the phenylsulfonate form of atracurium. Pure Cisatracurium besilate is a white crystalline powder that is a neuromuscular blocking agent. It binds to cholinergic receptors on the motor endplate to counteract the action of acetylcholine, resulting in competitive neuromuscular conduction block. The onset time is 1 minute and the duration is 15 minutes.
| Molecular formula |
|
|
|
Item |
Specification |
Results |
|
Appearance |
White or yellowish powder |
Light yellow powder |
|
Assay |
Cisatracurium besylate >98% |
98.86% |
|
Loss on Drying |
≤3.0% |
1.85% |
|
Mesh Size |
100% pass 80 mesh |
Complies |
|
Residue on Ignition |
≤1.0% |
0.86% |
|
PH |
5.5-7.0 |
Complies |
|
Heavy Metal |
≤10ppm |
<10ppm |
|
As |
<1.0ppm |
0.12ppm |
|
Cd |
<1.0ppm |
Complies |
|
Pb |
<2.0ppm |
0.24ppm |
|
Hg |
<1.0ppm |
Complies |
|
Total Plate Count |
<1,000cfu/g |
<100cfu/g |
|
Yeast & Mold |
<100cfu/g |
<30cfu/g |
|
E.Coli |
Negative/10g |
Negative |
|
Salmonella |
Negative/10g |
Negative |
| Conclusion: |
The results conform with the BP2010 |
|
What is the difference between this product and Atracurium besylate?
Atracurium besylate is a benzylisoquinoline based medium time non depolarizing muscle drug that undergoes Hofmann degradation and esterase hydrolysis in the body. It does not rely on liver or kidney function and is used for skeletal muscle relaxation during anesthesia in various surgical procedures. It is the preferred drug for muscle relaxation in elderly patients. Cisatracurium Besylate Powder is the phenylsulfonate form of Atracurium and a non depolarizing neuromuscular blocking agent. Compared with the current clinical major muscle relaxant anesthetics, Cisatracurium besilate has the characteristics of metabolism through non hepatic and non renal pathways and cardiovascular stability. Its muscle relaxant effect is three times stronger than that of Cisatracurium, and there are no cardiovascular side effects. It is mainly suitable for general anesthesia and can be widely used in tracheal intubation, liver and kidney dysfunction, cardiovascular surgery, as well as elderly and pediatric patients. Especially since this product does not have dose-dependent histamine release adverse effects, it has gradually replaced Vecuronium bromide and Atracurium besylate as the mainstream clinical muscle relaxants.
What are the adverse reactions of Cisatracurium besylate?
Adverse reactions that may occur when using Cisatracurium besylate include skin flushing, rash, bradycardia, hypotension, and bronchospasm. In addition, the main metabolite of this product is Laudanosine. (+-) - Laodanosine is a tertiary amino alkaloid, which is a moderately potent and uplifting product. However, because it is unbound during metabolism, it can easily cross the blood-brain barrier. It is highly likely to cause epilepsy or other cardiovascular and cerebrovascular diseases. Therefore, as one of the compound anesthetic drugs, phenylsulfonyl cis atracurium should be closely monitored for vital signs and changes in the patient's condition during use, especially considering that the plasma concentration of Laudanosine produced by Cisatracurium besylate is lower than that of atracurium. Once adverse reactions occur, the medication should be stopped immediately and corresponding treatment measures should be taken.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Cisatracurium besylate powder etc. at a more favorable price. If you are interested, please leave a message.
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