Product Introduction
Lumefantrine powder is a yellow crystalline powder. It is currently the most widely used antimalarial drug in my country. It is also the main drug ingredient of well-known antimalarial drugs. It can kill the asexual body of Plasmodium in the erythrocytic stage, with a high insecticide rate and a cure rate of about 95%, but it is ineffective against the pre-erythrocytic stage and gametocytes. Animal experiments show that it is a slightly toxic drug, but the mutagenicity and teratogenicity tests are negative. It is mainly used in the treatment of malignant malaria in clinical practice, especially for the treatment of malignant malaria resistant to chloroquine.
|
|
|
| Lumefantrine powder Picture | Lumefantrine powder MF |
Product Application
Lumefantrine powder is a new mefloquine drug created in my country. It has a significant killing effect on the sexual and asexual forms of Plasmodium vivax malaria, and has a good preventive effect on Plasmodium vivax malaria. It also has a killing effect on the asexual form of Plasmodium falciparum malaria, but the effect is slow. It can reduce the gametocyte rate in the blood and inhibit the development of gametocytes in mosquitoes. Trials in areas where chloroquine-resistant falciparum malaria is prevalent have shown that the cure rate for chloroquine-resistant or multidrug-resistant falciparum malaria is over 95%. When used in combination with artemether, the antimalarial effects of the two can complement each other. Lumefantrine has a thorough insecticide effect and a long-lasting effect, but it is slow to control symptoms. Artemether is fast-acting, but has a high relapse rate.
Lumefantrine and its internal standard halofantrine were extracted from plasma samples using protein precipitation with acetonitrile (0.2% perchloric acid) followed by solid-phase extraction with Hypersep C8 cartridges. Chromatographic separation was performed on a Zorbax SB-CN HPLC column (3.0 × 150 mm, 3.5 μm) with water/methanol (0.1% TFA) as the mobile phases in a gradient elution mode.
Detection was performed using UV/vis detector at λ = 335 nm. The method showed to be linear over a range of 50–10,000 ng/mL with acceptable intra- and inter-day precision and accuracy. The mean recoveries were 88.2% for lumefatrine and 84.5% for the I.S. The internal standard halofantrine is readily available from commercial sources. This method was successfully applied to a pharmacokinetic interaction study between a first-line antimalarial combination (artemether-lumefantrine) and antiretroviral therapy.
Product Specification
| Item | Specification | Result |
| Description | Yellow crystalline powder | Yellow crystalline powder |
| Identification | Infrared absorption spectrum | Infrared absorption spectrum |
| Specific rotation | +26.3 °- +27.7° | +26.9 °- +27.9° |
| [a]D20° | ||
| State of solution | --- | ≥ 98.0% |
| /Transmittance | ||
| Chloride (Cl) | ≤ 0.05% | ≤ 0.020% |
| Ammonium (NH4) | --- | ≤ 0.02% |
| Sulfate (SO4) | ≤ 0.03% | ≤ 0.020% |
| Iron (Fe) | ≤ 0.003% | ≤ 10PPm |
| Heavy metals (Pb) | ≤ 0.0015% | ≤ 10PPm |
| Arsenic (As2O3) | --- | ≤ 1PPm |
| Other amino acids | --- | Chromatographically not detectable |
| Loss on drying | ≤ 0.5% | ≤ 0.5% |
| Residue on ignition | ≤ 0.3% | ≤ 0.10% |
| (sulfated) | ||
| Assay | 98.5-101.5% | 99.0 - 101.0% |
| Conclusion | Conform with the enterprise standard | |
How To Obtain Samples Lumefantrine powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Lumefantrine powder.
The Best Lumefantrine powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Lumefantrine powder?
Faithfulbio specialize in Lumefantrine powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Lumefantrine powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Lumefantrine powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
Hot Tags: lumefantrine powder cas 82186-77-4, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China