Cyclosporin is a strong immunosuppressant that can inhibit the response of cellular mediators, reversibly inhibit T cell proliferation, and does not inhibit the generation of blood cells or affect phagocytic function. Therefore, compared with other inhibitors, it has the advantage of less inducing or aggravating infections. Cyclosporin A powder is a white needle shaped crystal with a melting point of 148-151 ℃, soluble in methanol, ethanol, acetone, ether or chloroform, and slightly soluble in water and saturated hydrocarbons.
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Items |
Standard |
Result |
|
Appearance |
White crystalline powder |
Conforms |
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Solublility |
To comply |
Conforms |
|
Identification |
To comply |
Conforms |
|
Loss on drying |
2.0%max |
0.6% |
|
Heavy metal |
0.002%max |
<0.002% |
|
Individual impurity |
0.7%max |
0.3% |
|
Sum ofall impurity |
1.5%max |
1.0% |
|
Any other impurity |
0.1%max |
0.05% |
|
Acetone |
0.5%max |
0.04% |
|
Ethanol |
0.5%max |
0.00% |
|
Ethyl acetate |
0.5%max |
0.07% |
|
ASSAY |
98.5%~101.5% |
99.23% |
|
CONCLUSION:THE PRODUCT CONFORMS TO USP36 |
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What is Cyclosporin A immunosuppressant?
Pure Cyclosporine is a lipophilic cyclic peptide compound composed of 11 amino acids isolated from the culture medium of certain Hyphomycetes fungi. It belongs to the category of potent immunosuppressants, which can inhibit the response of cellular mediators, reversibly inhibit T cell proliferation, do not inhibit the generation of blood cells, and do not affect phagocytic function. Therefore, compared with other inhibitors, Cyclosporin A powder has the advantage of less inducing or aggravating infections. It is mainly used clinically for anti rejection reactions in kidney, liver, heart, lung, and bone marrow transplantation, and can be used in combination with adrenal cortex hormones, but should not be used in combination with other immunosuppressants. It is also used for certain autoimmune diseases such as systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, and autoimmune hemolytic anemia. Used for treating conditions such as uveitis, severe aplastic anemia, refractory primary thrombocytopenic purpura, psoriasis, etc.
About the pharmacological action of this product?
Cyclosporine is inactive on the bone marrow, has little effect on B cells, and has no significant inhibitory effect on the survival of granulocytes at therapeutic doses. The main mechanism of action of pure cyclosporin A is that cyclosporine A forms a complex with cyclosporine and then acts on calcineurin, which depends on calcium/calcium binding protein, inhibiting the dephosphorylation of NF-AT and preventing it from entering the nucleus, thereby inhibiting the production of IL-2, inhibiting the killing activity of NK cells, and inhibiting the generation of T lymphocytes.
What is the research direction of this product?
This product is a fat-soluble drug, which can be absorbed by eating and eating fatty food. Bile deficiency, stagnation, slow gastric emptying, increased gastrointestinal peristalsis, pancreatic dysfunction and fatty dysentery all affect the absorption of this product.
Oral absorption is irregular and varies greatly among different individuals. The average bioavailability is 30%, but Cyclosporin A Powder can increase with the extension of treatment time and the increase of drug dosage. After liver transplantation, the absorption may decrease in patients with liver disease or gastrointestinal dysfunction. The binding rate of this product with plasma protein is as high as about 90%, mainly with lipoprotein.
Although its serious liver and kidney toxicity, poor solubility, narrow therapeutic index, and low bioavailability have hindered its further application in these fields. However, currently people are trying to modify its structure and synthesize a series of compounds, and searching for immunosuppressive agents with low toxicity and side effects, or derivatives with low toxicity and other biological activities even though they have no immunosuppressive activity.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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