Diclofenac Potassium Powder CAS 15307-81-0

Diclofenac potassium powder is a white to yellowish crystal; It has pungent feeling and moisture absorption. Soluble in methanol, soluble in ethanol and glacial acetic acid, slightly soluble in acetone and insoluble in chloroform.

What is the difference between diclofenac sodium and diclofenac potassium?

The difference between diclofenac potassium and diclofenac sodium lies in Product type, mechanism of action,Product efficacy, Scope of treatment,Product stability and so on.

1. Product type: Diclofenac sodium belongs to a non steroidal anti-inflammatory product.and diclofenac potassium belongs to another non steroidal anti-inflammatory product of diphenylacetic acid.
2.mechanism of action:Sodium diclofenac reduces the synthesis of prostaglandins by inhibiting the action of cyclooxygenase, thereby alleviating pain and reducing inflammation. Diclofenac potassium mainly exerts anti-inflammatory effects by inhibiting leukocyte mediated inflammatory responses.
3. Product efficacy: The ingredients contained in diclofenac sodium have analgesic and anti-inflammatory effects, and can be used to treat pain caused by various reasons.Diclofenac potassium not only has anti-inflammatory effects, but also has antipyretic effects, which can be used to treat fever caused by various reasons.
4. Scope of treatment:Diclofenac sodium is mainly used to alleviate mild to moderate pain symptoms, such as arthritis, muscle pain, headache, etc. Diclofenac potassium is commonly used to treat diseases caused by inflammation, such as rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc.
5. Product stability: Diclofenac potassium contains potassium ions, and its absorption process is relatively stable. Compared with diclofenac sodium, it has certain advantages in the absorption process, and after dilution in the body, it quickly exerts its analgesic effect. However, if the patient is hyperkalemic, diclofenac potassium cannot be selected. If there is no electrolyte disorder, you can choose to replace it.
Our company often develops different raw materials for nonsteroidal anti-inflammatory products to meet the needs of different customers, such as sodium diclofenac and potassium diclofenac. We currently have ample inventory. If you are interested, please leave a message via email :sales6@faithfulbio.com.

What are the effects of diclofenac potassium tablets?

The commonly used diclofenac potassium tablets in clinical practice are tablets made from pure diclofenac potassium through strict medical procedures. Diclofenac potassium powder is one of the clinically validated nonsteroidal anti-inflammatory products with stronger efficacy, and its inhibitory effect on prostaglandin synthesis is superior to aspirin. It has analgesic, antipyretic, anti-inflammatory, and joint swelling relieving effects.
1. Pain relief
Diclofenac potassium tablets have analgesic effects by inhibiting the activity of prostaglandin synthase and reducing the production of inflammatory mediators. In clinical practice, it is commonly used to treat mild to moderate pain such as headache, toothache, muscle pain, etc.
2. Relieve fever
Diclofenac potassium tablets can inhibit the synthesis and release of prostaglandin E in the hypothalamus, lower the temperature center's set point, and cause sweating to achieve the goal of fever relief. Especially for fever symptoms caused by common colds, this product has miraculous effects. In addition, inhibiting the synthesis of prostaglandins can also block the cell activity caused by pyrogens and improve the fever caused by infectious diseases or non infectious diseases.
3. Anti inflammatory
Diclofenac potassium tablets have anti-inflammatory effects by inhibiting the activity of cyclooxygenase in arachidonic acid metabolism, reducing the content of PGs. Under the guidance of a physician, it can be used to treat symptoms such as local redness, swelling, pain, and heat caused by diseases such as rheumatoid arthritis and osteoarthritis.
4. Relieve joint swelling
Diclofenac potassium tablets can inhibit the production of interleukin-1, thereby suppressing the chemotaxis and phagocytosis of macrophages, reducing inflammatory reactions, and alleviating joint swelling. Therefore, this product can also be used to alleviate joint swelling caused by diseases such as rheumatoid arthritis and ankylosing spondylitis.

In tooth extraction,Is the analgesic effect of diclofenac potassium really good?

Tooth extraction is a common routine dental operation in clinic, which may cause moderate to severe pain after operation. Preemptive analgesia is one of the anti-nociceptive treatments, which can prevent the change of central sensitization and relieve postoperative pain. Ibuprofen, acetaminophen and diclofenac potassium are the first choice products for preemptive analgesia. Studies have compared the efficacy of ibuprofen, acetaminophen and diclofenac potassium in relieving pain after tooth extraction in adults. It is found that diclofenac drugs have outstanding effects and can play a better preemptive analgesic role after the extraction of the third molar.

1.Comparison of Diclofenac Potassium, Ibuprofen, and Acetaminophen
Pain scores were performed on patients in the acetaminophen group and ibuprofen group, acetaminophen group and diclofenac potassium group, and ibuprofen group and diclofenac potassium group at 2, 4, and 6 hours after tooth extraction. We found that the potassium diclofenac group had the highest efficiency in relieving toothache (up to 55%). In a double-blind clinical trial, it was found that diclofenac (100mg) had a better analgesic effect than acetaminophen (500mg), and the analgesic time of diclofenac was longer than acetaminophen.

2. The mechanism by which diclofenac potassium is superior to ibuprofen and acetaminophen
The analgesic effect of diclofenac potassium is significantly better than that of ibuprofen and acetaminophen, which may be due to their different mechanisms of action. Diclofenac potassium and ibuprofen have similar mechanisms of action, both of which work by blocking the action of cyclooxygenase. Both diclofenac potassium and ibuprofen can inhibit the formation of prostaglandin receptors in the periphery. However, diclofenac potassium dissolves and absorbs faster than ibuprofen, takes effect quickly, and can alleviate early pain. Compared with the acetaminophen group, the differences in pain relief and their mechanisms of action are closely related. The antipyretic effect of acetaminophen is mainly achieved by inhibiting the synthesis of prostaglandin E in the hypothalamus, while the analgesic effect is achieved by blocking the impulse production in chemoreceptors sensitive to bradykinin. Compared with the direct inhibition of cyclooxygenase activity and indirect inhibition of leukotriene synthesis by diclofenac potassium, it feels more direct and has a more significant effect on the body.

In addition, joint and muscle sprains, tooth extractions, and surgeries generally cause aseptic inflammation, tissue edema, and local pain. The body often synthesizes and releases prostaglandins locally in the injured area, which is a normal stress response under the body's self-protection, but this can also exacerbate local pain. And this product can reduce the synthesis and release of prostaglandins in the injured area, reducing the tension of local tissues.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price. In terms of analgesic products, we can provide not only diclofenac sodium and diclofenac potassium, but also offer products such as aspirin, ibuprofen, and acetaminophen(Paracetamol). If you are interested, please leave us a message as soon as possible.

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