What is Bulevirtide?
Bulevirtide, also known as Burvitrilate, is a synthetic N-terminal myristic acid linear lipopeptide, consisting of 47 amino acids, with molecular formula C248H355N65O72 and molecular weight of 5398.86. It is a white to white powder, which is prepared by solid-phase peptide synthesis, with clear chemical structure, high purity and low impurity content. Burvitrilate is derived from the pre-S1 functional fragment of hepatitis B virus envelope protein, which has a hydrophobic side chain of nutmeg and can specifically recognize the transport receptor on the surface of liver cells. The powder showed good stability under sealed, cool and moisture-proof conditions, which revealed a new mechanism of virus entering inhibitors.
What are the target sites and mechanisms of action of Bulevirtide?
The core target is NTCP.NTCP is distributed on the outer basal side of the liver cell membrane and serves as both a bile acid transporter and an importantreceptor for the invasion of hepatitis B virus (HBV) and hepatitis D virus (HDV) into liver cells. Bulevirtide can competitively bind to NTCP receptors, occupy virus attachment sites, block the adsorption and invasion of hepatitis B virus and hepatitis D virus into liver cells, thereby preventing the spread and infection of the virus in the liver. Bulevirtide does not directly kill the virus, but blocks the pathway of virus infection in new liver cells, inhibits the continuous spread of the virus, and thus achieves the goal of controlling chronic hepatitis D infection.
In which fields is Bulevirtide primarily used?
1. Development of antiviral raw materials for pharmacological research related to chronic hepatitis D and hepatitis B, focusing on HBV and HDV co-infection.
2. In vitro cell experiments related to liver diseases for exploring the mechanisms of hepatocyte viral infection.
3. Development of novel targeted antiviral drugs as lead peptides for first-in-class viral entry inhibitors.
4. Research on physiological and pathological pathways related to the hepatocyte membrane NTCP receptor.
MF of Bulevirtide
CAS：2012558-47-1
Molecular Formula: C248H355N65O72
Molecular weight: 5398.86
Storage conditions: Dry powder -20℃, solution -80℃
Sequence: {Myr}-Gly-Thr-Asn-Leu-Ser-Val-Pro-Asn-Pro-Leu-Gly-Phe-Phe-Pro-Asp-His-Gln-Leu-Asp-Pro-Ala-Phe-Gly-Ala-Asn-Ser-Asn-Asn-Pro-Asp-Trp-Asp-Phe-Asn-Pro-Asn-Lys-Asp-His-Trp-Pro-Glu-Ala-Asn-Lys-Val-Gly‑NH₂
Product Specification
| Item | Specification | Result |
| Appearance | White to off-white powder | Complies |
| Identification | Consistent with reference standard | Complies |
| Purity (HPLC) | ≥98.0% | 99.21% |
| Peptide content | ≥95.0% | 96.75% |
| Residual solvent | Meet standard | Complies |
| Water Content | ≤8.0% | 4.13% |
| Heavy Metals | ≤10ppm | <10ppm |
| Conclusion | Complies with enterprise standard | |
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FAQ：
Q1: What is the core target of bulevirtide antiviral effect?
A: Bulevirtide targets the NTCP receptor on hepatocytes. By binding to NTCP, it blocks HBV and HDV from attaching to hepatocytes, preventing viral invasion.
Q2: Can bulevirtide directly eliminate viruses already present inside hepatocytes?
A: It cannot directly eliminate viruses already colonized and replicating within cells. It can only block viral infection of new hepatocytes and inhibit viral spread.
Q3: Which hepatitis virus is most effective against?
A: It is most effective against hepatitis D virus (HDV). HDV relies on HBV to complete its infection cycle, and bulevirtide can block persistent HDV infection.
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