What is Debrafenib API?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Debrafenib API belongs to the thiobenzenesulfonamide class of organic intermediates and features a fairly intricate molecular framework. Boasting the molecular formula C₂₃H₂₀F₃N₅O₂S₂, it has a molecular weight of 519.56. Under ambient‑temperature conditions, it generally appears as solid powder ranging in color from white to pale yellow, and its melting point falls within 214‑216 °C. The compound displays extremely low aqueous solubility and can barely be dispersed in water. On a molecular level, it demonstrates potent binding affinity toward BRAF‑mutated kinases. In‑vitro assays have confirmed its prominent target‑directed bioactivity, with nanomolar‑range IC50 values observed in laboratory tests.
Application of Debrafenib API
Debrafenib API CAS 1195765-45-7 is the free base of Dabrafenib. This substance is mainly used as a fine chemical raw material and is used in various in vitro experimental studies. It can be used to explore kinase-related mechanisms and test molecular binding characteristics. It can also be used as a basic material for salt conversion to prepare corresponding methanesulfonate derivatives. At the same time, it can be used in the laboratory to carry out structural modification, derivative synthesis, sample comparison and other related work. It is widely used in scientific research scenarios such as cell-level model exploration and activity screening.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white powder |
Conforms |
| Idenification(HPLC,RT match) | Conforms with reference standard |
Conforms |
| Identification(IR) | Conforms with reference standard |
Conforms |
| Assay(HPLC) | ≥99.0% | 99.6% |
| Water Content(Karl Fischer) | ≤0.5% | 0.2% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Heavy Metals | ≤10 ppm | Conforms |
| Related Substances-Single Impurity | ≤0.15% | 0.05% |
| Related Substances-Total Impurities | ≤0.5% | 0.18% |
| Residual Solvents | Conforms (ICH Q3C) | Conforms |
| Purity(HPLC,area %) | ≥99.5% | 99.8% |
| Conclusion | Conform with enterprise specification | |
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Density 1.443
Boiling point 653.7±65.0 °C (Predicted)
Molecular formula C23H20F3N5O2S2
Molecular weight 519.56
Flash point 349.2±34.3 °C
Exact mass 519.101074
PSA 148.21000
LogP 3.54
InChIKey BFSMGDJOXZAERB-UHFFFAOYSA-N
Mechanism of action of Debrafenib API
1. Debrafenib API specifically binds to the catalytic region of BRAF mutant proteins, occupying the active site within the protein and preventing substrate molecules from docking with it.
2. This substance can reduce the catalytic efficiency of mutant BRAF proteins, weaken the transduction intensity of downstream signaling pathways, and regulate intracellular signal transduction chains.
3. This molecule shows a clear binding preference only for specific mutant subtypes of BRAF proteins, with relatively limited effects on wild-type proteins.
4. Dabrafenib affects cell-level proliferation-related signal output by interfering with the aforementioned protein signal transduction processes, and is primarily used for mechanistic observation in in vitro systems.
5. It forms multiple intermolecular forces with target proteins to maintain their binding state, thereby achieving the regulatory effect on protein function.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. How should Dabrafenib be stored?
This substance needs to be stored in a sealed container away from light. For long-term storage, an environment of -20°C is recommended. Properly aliquot and isolate it from moisture. It can tolerate room temperature conditions for short-distance transport.
02. What are the characteristics of Dabrafenib?
Debrafenib API binds to the active sites of specific mutant BRAF proteins, reducing protein catalytic efficiency and interfering with downstream signal transduction. Its binding ability to wild-type BRAF proteins is weaker.
03. What precautions should be taken when handling this substance?
Proper protective measures should be taken during handling to avoid skin and respiratory contact with dust. The work environment should be well-ventilated, and it should not be discharged into water bodies.
Click email：Sales4@Faithfulbio.Com Or WhatsApp：+86 17782784907
Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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