Bis(Pinacolato)Diboron 99 CAS 73183-34-3

Bis(Pinacolato)Diboron 99% powder is an organic boron compound with the chemical formula C ₁ ₂ H ₂ ₄ B ₂ O ₄ and a molecular weight of 253.94. It appears as a white to off white powder or crystal and is a commonly used diborane reagent in organic synthesis as a boronizing agent. When using it, it should be noted that Bis (pinacolato) diboron API powder and Bis (pinacolato) diboron reagent are different. Reagent grade is mainly used for scientific research and laboratory synthesis, and purity requirements may vary (mainly depending on customer requirements). The Bis (pinacolato) diboron API needs to comply with relevant pharmacopoeia standards or internal control standards of the enterprise, and usually needs to be produced and provided according to the standards.

What is the purpose of Bis(Pinacolato)Diboron 99% powder?

Bis(Pinacolato)Diboron 99% powder is one of the most important boronizing reagents in organic synthesis. Its main uses include: as the key boron source in Suzuki-Miyaura coupling reaction, it reacts with electrophilic reagents such as halogenated aromatic hydrocarbons or aryl diazonium salts to construct carbon-carbon bonds, which are widely used in arylation modification of drug molecules, natural products and functional materials; As a boronizing reagent of Miyaura boronizing reaction, it directly reacts with aryl or alkenyl halides in the presence of palladium catalyst to produce pinacol aryl borate ester, which provides an important intermediate for subsequent coupling reaction. In addition, it also has important applications in C-B bond formation reactions such as Chan-Lam coupling and Petasis reaction. The reagent has excellent air stability, convenient operation and reactivity due to the protection of pinacol group, and is an indispensable synthetic building block in the fields of medicinal chemistry (such as the synthesis of anti-tumor and anti-virus drugs), material science (OLED materials, organic photoelectric materials) and the total synthesis of complex natural products, especially suitable for the preparation of borate compounds sensitive to water and oxygen and subsequent functional group conversion.

What is the market situation for Bis (pinacolato) diboron 99% powder ?

The current market situation of Bis (pinacolato) diboron powder shows obvious price differentiation and a basic balance between supply and demand. From a price perspective, there are significant differences in specifications and procurement channels, especially after the rapid development of China's industry. Reagent grade small packaging (1g-100g) fluctuates in an extremely low price range, while international brand reagent quotations are relatively high. Therefore, Chinese reagent brand prices are more competitive; The price of industrial bulk purchases (in kilograms and above) has significantly decreased. Depending on the purchase volume, some manufacturers can offer more favorable prices for ton orders (such as Xi'an Zhongshi). From the perspective of supply and demand, domestic production enterprises are mainly concentrated in Hubei, Jiangsu, Shandong and other places, with relatively sufficient production capacity to meet downstream needs such as pharmaceutical intermediates and organic synthesis. However, there is still a certain dependence on imports for high-end high-purity products (≥ 99.5%). Since 2025, due to fluctuations in raw material costs and environmental policies, prices have remained stable with a slight increase, but the increase has been limited. It is expected that the market will maintain stable operation in the short term, with price fluctuations within 5% -10%.

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FAQ:

Q1: What should I pay attention to when handling APIs?
It is necessary to operate in a well-ventilated environment (fume hood is recommended), and wear protective gloves, masks and goggles to avoid direct contact with skin, eyes or inhalation of dust. Thoroughly clean after operation. In case of contact, immediately flush with plenty of water and seek medical attention if necessary.
Q12: What are the safety risks of APIs?
It may cause skin irritation and eye irritation, and inhalation of dust may cause respiratory discomfort. Long-term or repeated contact may have adverse effects on health. See MSDS (Chemical Safety Technical Specification) for specific safety information.
Q3: How to deal with waste APIs?
It should be treated as hazardous chemical waste and entrusted to a qualified hazardous waste treatment unit for disposal. It is not allowed to be discarded or discharged into the sewer at will. Comply with local environmental laws and regulations.

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