Overview of 2 deoxyadenosine：
2 deoxyadenosine is a natural deoxyribonucleoside, which is a structural fragment of deoxyribonucleic acid DNA. Like other natural nucleosides,
2 deoxyadenosine participates in the transmission of genetic information in almost all biological cells, affects the synthesis of protein and the metabolism of polysaccharides, and plays a very important role in regulating the growth, proliferation, differentiation and inhibition of cells in organisms. It is not only an important raw material for gene medicine and genetic engineering research, but also has good physiological activity.
2 deoxyadenosine can inhibit insulin release induced by sugar, and can reduce the role of specific phosphodiesterase inhibitors or adenosine cyclase activators in promoting insulin secretion.2 deoxyadenosine appears as white powder, and its solubility is DMSO (a little), methanol (a little) and water (a little).
| Product name | 2 deoxyadenosine |
| CAS | 958-09-8 |
| Molecular formula | C10H13N5O3 |
| Molecular weight | 251.24 |
| EINECS Number | 213-488-7 |
| Melting point | 187-189 °C |
| density | 1.2938 (rough estimate) |
| boiling point | 394.4°C (rough estimate) |
| refractive index | 1.7610 (estimate) |
| Storage condition | Keep in dark place,Inert atmosphere,2-8°C |
| Acidity coefficient (pKa) | pK1:3.8(+1) (25°C,μ=0.1) |
| pH value | 3.8 |
| Maximum wavelength (λmax) | 258 (pH 2);260 (pH 7) |
| Water solubility | Soluble in water and caustic soda. |
| stability | hygroscopicity |
product Specification
| Item | Specification | Test Results |
| Appearance | White powder | Conform |
| Identification | TLC:Standard solution and test solution same spot,RF | Conform |
| Assay (Dry Basis) | 98.0%~100.5% | 99% |
| Specific Optical | -2.4°~ -2.8° | -2.71° |
| PH | 4.5~7.0 | 5.3 |
| Heavy Metals (As Pb) | ≤10ppm | <10ppm |
| As | ≤1ppm | Not Detected |
| Pb | ≤0.5ppm | Not Detected |
| Cd | ≤1ppm | Not Detected |
| Hg | ≤0.1ppm | Not Detected |
| Related substance | Spot not bigger than standard solution spot |
No spot |
| Residual solvent | <0.5% | Complies |
| Water Content | <2% | 0.18% |
| Conclusion: The test results are conformed to the in-house specification | ||
What is the synthesis process of 2 deoxyadenosine ?
The synthetic process of 2 deoxyadenosine mainly includes the following methods:
Esterification method:
Adenosine and dialkyl tin oxide are acylated under the action of esterifying agent to produce acylate. After reduction and purification, 2 deoxyadenosine was finally obtained.
Bromination debromination method:
Acylated deoxyadenosine compounds were prepared by debromination reaction with acylated bromoadenosine compounds as starting materials under the action of free radical initiator. 2 deoxyadenosine was obtained by hydrolysis under the action of inorganic base.
Enzymatic method:
2 deoxyguanosine was converted into 2 deoxyadenosine by using Brevibacterium Acetobacter enzyme to catalyze group migration.
Microbial transformation method:
Bacillus coagulans)DHE002 was cultured by fermentation, and it was used to catalyze the production of 2 deoxyadenosine.
The above preparation methods are in the research stage, only for academic research and technical discussion, and do not make actual preparation guidance methods, please make dialectical analysis.
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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