Temozolomide-Based Dry Powder CAS 85622-93-1

Temozolomide-Based Dry Powder, white or light brown/light pink powder, molecular formula: C6H6N6O2, molecular weight: 194.15100, density: 1.97 g/cm3, melting point: 212°C dec, boiling point: 526.6cat 760mmhg. It easily decomposes at pH7 and crystallizes from dichloromethane. Maximum UV absorption (95% ethanol): 327nm. Slightly soluble in dimethyl sulfoxide, slightly soluble in water, slightly soluble in methanol, almost insoluble in ethanol, and slightly soluble in glacial acetic acid. It can spontaneously and quickly degrade in vivo to produce MTIC, an active metabolite, and produce an anti-tumor effect.

What is Temozolomide?

Temozolomide-Based Dry Powder, due to its small molecular size, easily crosses the blood-brain barrier. Its efficacy is due to its non-cell cycle specificity, thus promoting its use in slow-growing tumors, such as pituitary adenomas. It is the only chemotherapy drug that has been confirmed to be effective in treating APAs and has successfully improved progression-free survival (PFS) and overall survival (OS).

Temozolomide can penetrate the blood-brain barrier, and its bioavailability is close to 100%. It can effectively treat newly diagnosed and relapsed glioblastoma and anaplastic astrocytoma. Temozolomide is currently the first-line glioma treatment drug. At present, there is more and more consensus on the efficacy of Temozolomide in treating low-grade glioma.

What is the purpose of temozolomide?

Temozolomide-Based Dry Powder can quickly penetrate the blood-brain barrier and is widely used to treat malignant brain tumors. Clinical treatment shows that temozolomide can induce tumor regression and symptom relief in patients with astrocytoma and glioblastoma multiforme. It can also treat melanoma.

Who forbids the use of temozolomide?

1. people allergic to temozolomide or dacarbazine (DTIC) are prohibited.

2. It is forbidden during pregnancy (see medication for pregnant and lactating women)

3. It is contraindicated in patients with severe myelosuppression.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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