Methotrexate powder, an orange crystalline powder, is easily soluble in carbonate solution of dilute alkali, acid, or alkali metal, slightly soluble in dilute hydrochloric acid, and almost insoluble in water, ethanol, chloroform, and ether. Melting point: 195°C, storage condition: −20°C, solubility: H2O: insoluble, water solubility: Insoluble. Less than 0.1g/100ml at. Merck：5985, melting point: 195°C, boiling point: 561.26 C (rough estimate), density: 1.4080(rough estimate)
Methotrexate is a kind of drug used to treat cancer, also known as cellular poison. In order to reduce its cytotoxicity, it can be used together with calcium formyltetrahydrofolate, which is mainly used to treat acute leukemia, etc.
Methotrexate is also an immunosuppressant, which can alleviate the process of rheumatism, and has a particularly good therapeutic effect on synovitis of rheumatoid arthritis. It is one of the drugs most used by patients with rheumatoid diseases.
What is Methotrexate?
Methotrexate powder, as a classic immunosuppressant, is a derivative of methotrexate, which is a folic acid antagonist and was originally used to treat hematological malignancies. Methotrexate has been used to treat psoriasis for more than 50 years. According to the worldwide guidelines, methotrexate is currently the first-line systemic treatment drug for psoriasis.
Methotrexate, an anti-folate anti-tumor drug, mainly inhibits the synthesis of tumor cells by inhibiting dihydrofolate reductase and inhibits the growth and reproduction of tumor cells.
|
|
Real shot pictures of Methotrexate raw powder | Methotrexate structure diagram |
What are the interactions between Methotrexate and other drugs?
1. Ethanol and other drugs that are harmful to the liver, such as Methotrexate powder, can increase the toxicity of the liver.
2. Because the level of uric acid in the blood can increase after using Methotrexate, the dosage of allopurinol and other drugs should be increased correspondingly for patients with gout or hyperuricemia.
3. It can increase the anticoagulant effect, and even cause the deficiency of liver coagulation factors or (and) thrombocytopenia. It should be used with caution with other anticoagulants.
4. When it is used together with phenylbutazone and sulfonamides, it may cause an increase in serum concentration of Methotrexate and lead to a toxic reaction due to the competition with protein.
5. It is equivalent to weak organic acid and salicylate, which can inhibit the renal excretion of Methotrexate, leading to the increase of serum drug concentration, and then the increase in toxicity, so the dosage should be reduced as appropriate.
6. Drugs such as aminopterin and pyrimethamine have anti-folic acid effects, and if used together with Methotrexate, it can increase its toxic and side effects.
What are other precautions for using methotrexate?
1. Test before and after medication.
2. Appropriate folic acid supplementation
3. No drinking.
4. Follow the doctor's advice for combined medication.
5. Pay attention to contraception and prohibit breastfeeding.
How to choose more products
Nilotinib | 641571-10-0 |
Toremifene Citrate | 89778-27-8 |
Sodium dichloroacetate | 2156-56-1 |
Ribonucleic Acid | 63231-63-0 |
sorafenib tosylate | 475207-59-1 |
Vinblastine Sulfate/Vinblastine Sulphate | 143-67-9 |
vincristine | 57-22-7 |
Topotecan hydrochloride | 119413-54-6 |
Flutamide | 13311-84-7 |
Lomustine | 13010-47-4 |
Lenvatinib mesylate | 857890-39-2 |
Dasatinib | 302962-49-8 |
Oxaliplatin | 61825-94-3/63121-00-6 |
Sunitinib malate | 341031-54-7 |
Irinotecan | 97682-44-5 |
Irinotecan Hydrochloride | 100286-90-6 |
Lenalidomide | 191732-72-6 |
Doxorubicin hydrochloride | 25316-40-9 |
Pirfenidone | 53179-13-8 |
bicalutamide | 90357-06-5 |
Cyclophosphamide | 50-18-0 |
Temozolomide | 85622-93-1 |
Methotrexate/Trexall | 59-05-2 |
Anastrozole/Anastrazole/Arimidex | 120511-73-1 |
Tamoxifen | 10540-29-1 |
Tamoxifen citrate | 54965-24-1 |
Trilostane | 13647-35-3 |
Exemestane | 107868-30-4 |
Ruxolitinib | 941678-49-5 |
Ruxolitinib phosphate | 1092939-17-7 |
Sirolimus /rapamycin | 53123-88-9 |
Indole 3 Carbinol / | 700-06-1 |
3,3'-Diindolylmethane | 1968-05-4 |
Send your Inquiry for more details, Click email：allen@faithfulbio.com Now.
You can also contact me via WhatsApp：+86 13137770562
A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
Disclaimer: The articles published on this site are mainly used to promote academic exchanges and learning, and do not mean that this site agrees with its views or confirms the authenticity of its contents. Please filter carefully. If you believe this article is infringing, please contact the administrator. We are not responsible for the consequences of using the information and services on this website.
Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
Hot Tags: methotrexate powder cas 59-05-2, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China