Raw Powder Sorafenib Tosylate CAS 475207-59-1

Raw Powder Sorafenib tosylate is a clinical anticancer agent for the treatment of liver and renal cell carcinoma. It is mainly used to treat inoperable advanced renal cell carcinoma or primary hepatocellular carcinoma with distant metastasis.

At present, there is a lack of randomized controlled clinical research data comparing sorafenib with interventional therapy such as hepatic artery chemoembolization (TACE) in patients with advanced hepatocellular carcinoma. Therefore, it is not clear whether sorafenib is good or bad relative to interventional therapy, nor whether sorafenib is beneficial to patients who have previously received interventional therapy. It is suggested that doctors should comprehensively consider the specific situation of patients and choose appropriate treatment methods.

What is the pharmacological action of Sorafenib tosylate?

Raw Powder Sorafenib tosylate is a multi-kinase inhibitor. It can inhibit a variety of kinases existing in and on the surface of cells, including Raf kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), and platelet-derived growth factor receptor - β (PDGFR－ β), Kit and Flt-3, etc.

It can be seen that Sorafenib tosylate has two-tier antitumor effects. On the one hand, it can directly inhibit tumor growth by inhibiting Raf / MEK / ERK signal transduction pathway; On the other hand, it can inhibit VEGFR and PDGFR to block the composition of tumor regeneration vessels and directly inhibit the growth of tumor cells. Compared with oral solution, the relative bioavailability of tablets was 38% ~ 49%; a High-fat diet can reduce the bioavailability of sorafenib by 29%. The peak time of this product is about 3 hours, the uniform elimination half-life is about 25 ~ 48 hours, and the plasma protein binding rate is 99.5%.

Sorafenib is mainly oxidized and metabolized by liver metabolic enzyme CYP3A4 and glucosidic acidification by UGT1A9. It is now known that sorafenib has 8 metabolic products, of which 5 can be detected in the plasma of patients after sorafenib reaches the steady state. Sorafenib is mainly secreted with feces in the form of the prototype (accounting for 51% of the total dose) and metabolites, and some glucosidic acidification metabolites (accounting for 19% of the total dose) are secreted with urine.

What is the research on the anticancer effect of this product?

Researchers from many countries reported in the new issue of the New England Journal of medicine that they studied 602 patients with advanced liver cancer in the United States, Europe, and Australia. None of these patients had received systematic treatment. The results showed that compared with placebo, the overall survival of patients with advanced or primary liver cancer was prolonged by about 44%.

One of the leading investigators of the study, Jordi Brucks of Barcelona clinical hospital in Spain, said the number of deaths from liver cancer worldwide is still rising due to the epidemic of hepatitis B and hepatitis C. The new research results show that as a new choice for the treatment of liver cancer, Sorafenib tosylate powder can prolong the survival time of patients, which is encouraging.

Duojimei is produced by Bayer medical and health care company in Germany. It can act on tumor cells and tumor blood vessels at the same time. Relevant researchers once introduced at the annual meeting of the American Society of clinical oncology that they conducted a study on patients with advanced liver cancer in the Asia Pacific region and found that Raw Powder Sorafenib tosylate could prolong the survival of these patients by about 47%.

The drug has been approved in the United States and Europe for the treatment of liver cancer. Bayer healthcare recently issued a press release saying that doggy has been approved by China's State Food and Drug Administration for the treatment of patients with inoperable advanced liver cancer.

What are the precautions and adverse reactions of Sorafenib toluene sulfonate ?

Side effects of Raw Powder Sorafenib tosylate: 1 Bone marrow suppression is dose-limiting toxicity, which can cause leukopenia and thrombocytopenia, which can be recovered 1 ~ 2 weeks after drug withdrawal; 2. Sometimes gastrointestinal reactions occur, and there are reports of testicular atrophy and teratogenesis; 3. There are occasional central nervous system symptoms and hair loss, and there are also reports of drug-induced fever caused by this drug, which can reappear when repeated administration.

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