Dabogratinib CAS 2800223-30-5
Product:Dabogratinib;TYRA-300
CAS NO.:2800223-30-5
Molecular formula:C25H24Cl2N6O3S
Purity & Grade: 99% HPLC; Food grade
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 36 months
Lead Time: about 3 days
Warehouse: USA and Germany warehouse
Certificate:COA; HPLC; MSDS; TDS,etc.
Description
What is Dabogratinib?
Dabogratinib is a potent, selective, and orally active inhibitor. It can avoid toxicity associated with pan FGFR inhibitors and target key mutations in FGFR3.
| Product name | Dabogratinib |
| CAS | 2800223-30-5 |
| Molecular formula | C25H24Cl2N6O3S |
| Molecular weight | 559.47 |
| EINECS Number | NA |
| melting point | NA |
| solubility | NA |
| Storage conditions | NA |
| Appearance | white powder |
| boiling point | 791.2±70.0 °C |
| Density | 1.58±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr) |
Product Specification
| Item | Specification | Results |
| Appearance | White powder | Conforms |
| Assay(%) | ≥99.0% | 99.38% |
| Density(25/25ºC) | 1.58±0.1 g/cm3 | Conforms |
| As(mg/kg) | ≤3 | Conforms |
| Heavy Metal(Pb)% | ≤10 | Conforms |
| Refractive index(20ºC) | 1.3910-1.3970 | 1.3968 |
| Boiling point ºC | 791.2±70.0 °C | 83.5°C |
| Conclusion | Conform with enterprise specification | |
Where is Dabogratinib used?
Dabogratinib is a small molecule drug mainly used in the following fields:
Cancer treatment research: it is currently in clinical phase II, and is used to treat bladder cancer, urological tumor, urothelial cancer, solid tumor and metastatic epithelial cancer.
Research on chondrodysplasia: It can also be used for related studies on chondrodysplasia
In summary, it is mainly used in cancer treatment research and cartilage dysplasia research, but it has not yet been approved for human treatment and is still in the clinical trial stage.
What are the effects of Dabogratinib?
Dabogratinib has the following effects:
Antitumor activity: It has anti-tumor activity against urothelial carcinoma and solid tumors, targeting key mutations in FGFR3 and avoiding toxicity associated with pan FGFR inhibitors.
Selective inhibition: In the Ba/F3 cell line, its IC50 value is 11nM, and its selectivity for FGFR1, FGFR2, and FGFR4 is 25 fold, 14 fold, and 36 fold, respectively.
Research purpose: It can be used in the research of achondroplasia and the treatment of muscle invasive bladder cancer.
It should be noted that it is still in the research stage and its effectiveness in medical applications has not been fully validated, limited to scientific research purposes.
How and where to buy Dabogratinib wholesale?
Our products undergo experimental testing and are recognized by customers.
You can trust our order because we have a good record of selling legal educational drugs.
Send your Inquiry for more details, Click email：sales2@faithfulbio.com Now.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details, Click email：sales2@faithfulbio.com Now.
FAQ：
Q1: What's your delivery time?
A1:Usually we will arrange the shipment in 1 -3 days.
Q2:When can I Get Reply?
A2:Our Area sales manager will contact you as soon as possible in 24 hours one working day!
Q3: How about the validity of the products?
A3:According to the products you ordered.The usual shelf life is 2 years.
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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