99% Purity Lenalidomide Powder has been successfully used in the treatment of inflammatory diseases and cancer. The indications approved by FDA are: combined with dexamethasone in the treatment of multiple myeloma (mm); As maintenance therapy for mm after autologous hematopoietic stem cell transplantation. However, what many patients don't know is that it can also be used in hepatocellular carcinoma. Let's talk about this product briefly today.
| Molecular formula |
|
|
|
Item |
Specification |
Results |
|
Appearance |
Light yellow liquid |
conform to |
|
odor |
Has a special fragrance |
conform to |
|
Heavy metals (as Pb) |
≤1ppm |
0.0058ppm |
|
Total Plate Count |
<1,000cfu/g |
32.8cfu/g |
|
E.Coli |
<10cfu/g |
0.25cfu/g |
|
Salmonella |
None detected in 10g |
Absent |
|
Yeast and Mould |
NMT 100 cfu/g |
Absent |
| Conclusion： |
Conform with enterprise specification . |
What is the biological activity of lenalidomide?
99% Purity Lenalidomide Powder(CC-5013) is a TNF- α Secretion inhibitor, IC50 was 13 nm in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin e3ligasecereblon (CRBN), which causes the selective ubiquitination and degradation of two lymphoid transcription factors IKZF1 and ikzf3 through CRBN-crl4 ubiquitin ligase. Lenalidomide can promote the expression of cleaved caspase-3, inhibit the expression of VEGF and induce apoptosis.
What is the mechanism of action of this product?
99% Purity Lenalidomide Powder is an immunomodulatory drug, which has a variety of action mechanisms. In in vitro research, lenalidomide has three main functions: 1. direct antitumor effect, 2. inhibition of angiogenesis, and 3. immunomodulation. In vivo, lenalidomide can directly or indirectly induce the apoptosis of tumor cells by inhibiting the support of bone marrow stromal cells, anti-angiogenesis, and anti osteoclast, as well as immunomodulatory activity. At the molecular level, lenalidomide has been shown to interact with ubiquitin E3 ligase and target the enzyme to degrade Ikaros transcription factors IKZF1 and ikzf3.
History of lenalidomide
Lenalidomide raw material is an anti-tumor drug developed by Celgene biopharmaceutical company in the United States. Its chemical structure is similar to thalidomide and has multiple effects such as anti-tumor, immune regulation, and anti-angiogenesis. In December 2005, the US Food and Drug Administration (FDA) approved lenalidomide for the treatment of myelodysplastic syndrome (MDS). In March 2006, FDA approved lenalidomide produced by Celgene biopharmaceutical company in the United States for the treatment of multiple myeloma (mm). On September 23, 2011, the European Drug Administration (EMA) released information that it has confirmed that the benefits of lenalidomide in its approved patient population outweigh the risks, but also warned doctors about the risk of new cancer caused by the drug.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide 99% Purity Lenalidomide Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: 99% purity lenalidomide powder cas 191732-72-6, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China