Bicalutamide Powder CAS 90357-06-5

Bicalutamide powder is a non steroidal androgen antagonist. It competes with androgen for the androgen receptor, blocks the uptake of androgen by cells, and inhibits the binding of androgen to target organs. After binding with the androgen receptor, bicalutamide forms a receptor complex enters the nucleus, and binds with nucleoprotein, so as to inhibit the growth of tumor cells; This product is used in combination with luteinizing hormone-releasing hormone (LHRH) analog or surgical orchiectomy for the treatment of advanced prostate cancer. It is also one of the first-line drugs for the treatment of advanced prostate cancer.

Why is the side effect of this product gender-dependent?

The side effects of Bicalutamide powder are highly gender-dependent; In men, due to androgen deprivation, there may be various side effects with different severity during bicalutamide treatment, among which the most common are breast pain/tenderness and male breast development (breast development/enlargement). In addition to breast changes, men may show demasculinization, including reduced hair growth, decreased muscle mass and strength, female changes in fat volume and distribution Penile length is shortened and semen/ejaculation volume is reduced. Other side effects observed in men and similar to androgen deprivation include hot flashes, sexual dysfunction (e.g., decreased libido, erectile dysfunction), depression, fatigue, weakness, and anemia. However, most men retain sexual function through bicalutamide monotherapy. In women, due to the minimal biological importance of androgens in this gender, there are few side effects of pure antiandrogens or NSAA, and bicalutamide has been found to be well tolerated. Therefore, this product is suitable for women. Other common side effects of bicalutamide include diarrhea, constipation, abdominal pain, nausea, dry skin, pruritus, and rash. However, the drug is well tolerated at a dose of 50 mg/day with few additional side effects.

How should we match related products?

Bicalutamide powder is almost completely metabolized by CYP3A4. Therefore, inhibitors and inducers of CYP3A4 may change their levels in vivo. (see here for a list of CYP3A4 inhibitors and inducers.) However, although bicalutamide is metabolized by CYP3A4 when the dose of bicalutamide is 150 mg/day or less, it is combined with drugs that inhibit or induce cytochrome P450 enzyme activity.

Because bicalutamide circulates at relatively high concentrations and is highly bound to proteins, it may replace other highly protein-bound drugs such as warfarin, phenytoin, theophylline, and aspirin from plasma binding proteins. In turn, this may lead to an increase in the free concentration and effects and/or side effects of such drugs, which may require dose adjustment. Bicalutamide was found to replace coumarin anticoagulants such as warfarin from plasma binding protein (i.e. albumin) in vitro, which may increase the anticoagulant effect. Therefore, when bicalutamide is used in combination with these drugs, it is recommended to closely monitor the prothrombin time and adjust the dose if necessary. Nevertheless, no conclusive evidence of bicalutamide interaction with other drugs was found in clinical trials of nearly 3000 patients.

Other tips about this product

Bicalutamide tablets are an anti-androgen noncortical steroid used as an adjuvant in the treatment of advanced prostate cancer. Bicalutamide capsule has a good inhibitory effect on androgen, reduces the stimulation of androgen to the tumor, and effectively prevents the pathological development of prostate cancer. It is combined with luteinizing hormone-releasing hormone (LHRH) analog live surgical orchiectomy for the treatment of advanced prostate cancer. The treatment with this product should start at the same time as LHRH analog or surgical orchiectomy. It is recommended to consult the doctor and take it half an hour before or half an hour after meals according to the actual situation of the patient.

Bicalutamide capsules and flutamide tablets are anti-androgen drugs. The difference lies in the different components. The components of bicalutamide capsules are bicalutamide; The ingredients of flutamide tablets are flutamide; Therefore, the effects of the two drugs are different, and the medication methods and doses are also different.

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