Ruxolitinib phosphate is the phosphate form of ruxolitinib, It is a white crystalline powder with the molecular formula: C17H21N6O4P and molecular weight: of 404.360.
99% Ruxolitinib Phosphate is an effective JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM, which is 130 times higher than JAK3 selectivity.
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Real shot pictures of Ruxolitinib Phosphate powder | Ruxolitinib Phosphate structure diagram |
In vitro study of Ruxolitinib phosphate
99% Ruxolitinib Phosphate effectively and selectively inhibits JAK2V617F-mediated signal transduction and proliferation.
Ruxolitinib phosphate inhibited the growth of HEL cells with an EC50 of 186 nM.
Ruxolitinib phosphate significantly increased the apoptosis of the Ba/F3-EpoR-JAK2V617F cell system and inhibited the proliferation of hematopoietic progenitor cells in samples of patients with primary MPN.
In vivo study of Ruxolitinib phosphate
99% Ruxolitinib Phosphate can reduce the tumor burden of mice inoculated with JAK2V617F expression cells, without causing anemia or lymphopenia.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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