Sulfasalazine API Powder CAS 599-79-1

Sulfasalazine Introduction

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Sulfasalazine appears as an orange powder. Its CAS number is 599-79-1; its molecular formula is C18H14N4O5S; its molecular weight is 398.39; its EINECS number is 209-974-3. It is a type of Sulfanilamide antibacterial product. Originally, it was used for inflammatory bowel diseases, namely Crohn's disease and ulcerative colitis, with dual effects of anti-inflammatory and antibacterial. After the 1970s, it was found that it could alleviate joint pain, swelling, and stiffness in ankylosing spondylitis, and could also lower serum IgA levels and other laboratory active indicators. It was particularly suitable for improving peripheral arthritis in patients with ankylosing spondylitis and had the effect of preventing recurrence and alleviating the lesion of this disease when it was complicated with anterior uveitis. With the progress of research, it has gradually been applied to rheumatoid arthritis. Up to now, Sulfasalazine API Powder has been widely used in the treatment of rheumatoid arthritis and spinal joint diseases.  

What is the mechanism of action of Sulfasalazine?

Sulfasalazine is a preparatory productactive intermediate. Its efficacy is achieved through the synergistic action of multiple effects such as targeted intestinal release, alleviation of inflammation, and regulation of the immune system. After oral administration, most of the raw materials will not be decomposed and absorbed in the stomach and small intestine, but will reach the colon intact. The azo reductase secreted by the colonic flora will break the azo bond and split it into two active metabolite components: 5-Aminosalicylic acid and Sulfapyridine.
For research scenarios related to intestinal inflammation such as ulcerative colitis and Crohn's disease, 5-Aminosalicylic acid plays a core role. It can remain at the affected area of the intestine, blocking the generation of pro-inflammatory substances such as Prostaglandin E2 and LEUKOTRIENE F4, and alleviating the inflammatory state of the local mucosa. In rheumatoid arthritis-related experiments, Sulfasalazine that enters the circulation system along with the prototype raw material will regulate the immune state at the systemic level, calm down the excessive and abnormal immune responses of the body, and is mainly used for adult and juvenile rheumatoid arthritis-related research where the conventional conditioning scheme is ineffective.
In addition, the Sulfasalazine API Powder also intervenes in the human Folic acid metabolic pathway, competitively binding to the enzymes related to Folic acid metabolism, further assisting in the regulation of excessive immune reactions. By relying on the unique action path of local alleviation of inflammation in the intestine and systemic regulation of immunity through division of labor cooperation, this raw material can simultaneously adapt to both in vitro and in vivo studies related to intestinal and joint inflammatory conditions.

Why can Sulfasalazine simultaneously treat both enteritis and arthritis?

Sulfasalazine API Powder can simultaneously alleviate both intestinal inflammation and joint inflammation. The key reason lies in its unique substance and dual-action mechanism. It is a preformulated raw material that does not take effect directly upon entering the body. Instead, it reaches the colon and, under the action of intestinal flora, decomposes into two active components, 5-Aminosalicylic acid and Sulfapyridine. These two components work separately to address inflammation reactions in different parts.
Among them, 5-Aminosalicylic acid is hardly absorbed by the intestines and can remain on the surface of the colonic mucosa for a long time. By inhibiting the production of pro-inflammatory mediators such as Prostaglandin E2 and LEUKOTRIENE F4, it specifically alleviates local inflammatory conditions in conditions like ulcerative colitis and Crohn's disease. The decomposed Sulfapyridine can enter the human circulation system and regulate the immune state at the overall level, calming down the abnormal and excessive inflammatory responses, thereby addressing immune-related inflammatory issues related to rheumatoid arthritis.
Although intestinal inflammation and joint inflammation have different onset locations and external manifestations, their essence both stems from immune disorders causing imbalance in inflammation. Sulfasalazine relies on a dual-action mode of local inflammation relief in the intestines and systemic immune regulation, which enables it to adapt to both types of inflammation-related research scenarios. This collaborative and two-way coverage characteristic also makes it a classic raw material category that balances both intestinal and joint inflammation research.

MF of Sulfasalazine

CAS	599-79-1
Molecular formula	C18H14N4O5S
Molecular weight	398.39
EINECS	209-974-3
Melting point	260-265 °C
Boiling point	689.3±65.0 °C
Density	1.3742

Specification

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FAQ: 

Q1:The connection between folic acid and Sulfasalazine?
Because this product has an anti-folic acid effect, it can interfere with the absorption and metabolism of folic acid. Long-term use may lead to a deficiency of folic acid, which in turn can cause megaloblastic anemia. Therefore, it is necessary to take additional folic acid supplements to prevent this.
Q2:Is sulfasalazine extracted from nature or synthesized chemically?
It is completely chemically synthesized. It is formed by connecting the two molecules of Sulfapyridine and 5-Aminosalicylic acid through a diazo coupling reaction, and it is not extracted from animals or plants.
Q3:Can sulfasalazine be used during lactation?

Sulfasalazine and its metabolites can enter breast milk in small amounts. Although the risk is relatively low for most full-term healthy infants, it may cause hemolysis in infants with G6PD deficiency. Therefore, during lactation, their use should be done with caution under the assessment of a doctor.

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