Finerenone Powder CAS 1050477-31-0

Finerenone powder is a highly selective and novel active mineralocorticoid receptor antagonist, which can delay the progression of chronic kidney disease. The appearance of pure FIN is white to off-white solid, which can relieve proteinuria of patients and improve glomerular filtration rate. It is mainly used for the treatment and research of diabetic nephropathy, chronic nephropathy and end-stage renal disease. However, BAY 94-8862 may induce hyperkalemia, hypotension and hyponatremia, itching, decreased glomerular filtration rate and other adverse symptoms during use.

What is the pharmacological effect of Finerenone?

Finerenone powder is a nonsteroidal, selective mineralocorticoid receptor (MR) antagonist. Natural Finerenone raw material is a mineralocorticoid produced by the adrenal cortex, which mainly acts on the distal tubules and collecting ducts of the glomerulus, promoting sodium reabsorption and potassium secretion. We know that MR is mainly expressed in the heart, kidneys, and blood vessels. Excessive activation of MR can cause endothelial dysfunction, fibrinolysis disorders, oxidative stress, and cardiovascular and renal fibrosis, ultimately leading to organ damage, dysfunction, and even failure. Corticosteroid receptor antagonists (MRA) can achieve cardiorenal protection by inhibiting inflammation and fibrosis caused by MR activation. The novel nonsteroidal MRA Finerenone, with its high selectivity and effective blockade of MR, reduces inflammatory response and alleviates symptoms of myocardial remodeling and fibrosis, providing definite cardiorenal protection.

What are the advantages of Finerenone?

HOT SALE Finerenone is a powerful non-steroidal selective mineralocorticoid receptor (MR) antagonist, which can delay the progression of chronic kidney disease. We know that some customers have heard of the second-generation mineralocorticoid receptor antagonist Eplerenone, and Finerenone is the latest third-generation mineralocorticoid receptor antagonist. After use, you will find that FIN has unique pharmacological characteristics, which is the key to distinguish it from other steroid mineralocorticoid receptor antagonists. The first generation mineralocorticoid receptor antagonist is effective but not selective, and the second generation mineralocorticoid receptor antagonist Eplerenone is more selective but less effective. BAY 94-8862 is not only effective but also selective. Clinical studies have found that Finerenone can directly and simply block MR-mediated sodium reabsorption and MR overactivation in epithelial (such as kidney) and non-epithelial (such as heart and blood vessels) tissues, and has no affinity for androgen, progesterone, estrogen and glucocorticoid receptors. In addition, the pharmacokinetics of BAY 94 8862 and steroid mineralocorticoid receptor are also different. BAY948862 has the smallest urinary excretion, short half-life (2~3 hours) and no active metabolites. On the contrary, the first generation mineralocorticoid receptor antagonists have a long half-life and a variety of bioactive metabolites, which are easy to accumulate in patients with impaired renal function. Although the drug concentration accumulation of Eplerenone in kidney and heart has been alleviated, there are still some risks. The unique balanced kidney-heart distribution of BAY 948862 makes Finerenone powder have the potential to study heart and kidney diseases such as type 2 diabetes and chronic kidney disease.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Finerenone Powder etc. at a more favorable price. If you are interested, please leave a message.

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