Cefotaxime Powder CAS 63527-52-6

Cefotaxime is a white to white hygroscopic solid powder, which is easily soluble in water. The dilute solution is colorless or yellowish, and it is grayish yellow when the concentration is high. It is dark yellow or brown when metamorphic. Pure Cefotaxime is the third generation cephalosporin antibiotic, and its clinical effect on gram-negative bacilli and positive bacilli is obviously better than that of the first and second generation cephalosporins.

What are the pharmacological properties of Cefotaxima acid?

Cefotaxima acid is a semi-synthetic oxime cephalosporin, which is suitable for lower respiratory tract infection, urinary system infection, biliary tract and intestinal infection, skin and soft tissue infection, burns and bone and joint infection. In the mouse model, high purity Cefotaxime powder is highly stable against the broad-spectrum β -lactamases produced by gram-negative bacilli and negative bacilli, but if Cefotaxima acid is combined with ciprofloxacin, it is more effective to remove Vibrio vulnificus than cefotaxime acid alone.

What are the advantages of the third generation cephalosporins?

Cefotaxime, as the third generation cephalosporin, has obvious characteristics and advantages. From the antibacterial spectrum, cefotaxime sodium (Because cefotaxime has a single structure, its sulfur group will break under severe conditions. However, the structure of cefotaxime sodium hydrochloride after secondary processing is stable, and it is not easily affected by external factors, and it is more mild in allergic reaction.)has a stronger effect on gram-negative bacteria, especially on Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus and so on. This makes it play an important role in the treatment of serious infections caused by these gram-negative bacteria, such as pneumonia, abdominal infection, sepsis and so on. From the pharmacokinetic characteristics, cefotaxime sodium has good tissue penetration and can be widely distributed in the body, including cerebrospinal fluid and other parts, which is of great significance for treating some infections in deep tissues or special parts. From the perspective of antibacterial mechanism, the third generation cephalosporins are more effective than the first and second generation cephalosporins in inhibiting the synthesis of bacterial cell walls, and have lower affinity for β -lactamases and higher affinity for pbps. However, it should be noted that this product is not as effective as the first and second generations in dealing with G+ bacteria, and it is not as good as the fourth and fifth generations in plasma half-life and renal toxicity.

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