What is Nirmatrelvir API powder ?
Nirmatrelvir is a 3CL protease inhibitor with high activity and high selectivity. As a white to off-white crystalline powder, its chemical essence is a peptidomimetic compound. Through the binding of active sites, Nirmatrelvir API powder can effectively inhibit the activity of the enzyme and block the processing of viral polyprotein precursors, so that the virus cannot produce functional replicase, and finally effectively curb the replication and proliferation of the virus in the host cell. Its research and development is based on structural biology and rational design, and it has broad-spectrum inhibition potential for coronavirus. Its production process involves complex multi-step organic synthesis and strict purification process to ensure extremely high chemical purity, chiral purity and low impurity content, which meets the stringent standards of various countries.
| Product name | Nirmatrelvir API powder |
| CAS | 2628280-40-8 |
| Molecular formula | C23H32F3N5O4 |
| Molecular weight | 499.53 |
| EINECS | 605-001-5 |
| Boiling point | 742.4±60.0 °C(Predicted) |
| Density | 1.267±0.06 g/cm3(Predicted) |
| The acidity coefficient (PKA) | 10.26 0.46 (predicted) |
| Storage condition | Sealed in dry,Room Temperature |
What is the action mechanism of Nirmatrelvir API powder ?
Its action process can be divided into the following key steps:
1. Target recognition: After the virus invades human cells, it will use its own "translation machine" to produce a long polyprotein chain. This long chain must be "cut" into multiple functional virus proteins before the virus can replicate. The key "molecular scissors" to perform this "shearing" task is 3CL protease (also known as main protease).
2. Precise inhibition: Nirmatrelvir API powder is a peptidomimetic inhibitor specially designed for 3CL protease activity center. Its molecular structure mimics the substrate sequence normally cleaved by protease, and it can be perfectly embedded and closely bound to the active site of 3CL protease.
3. Covalent reversible binding: it covalently binds to the L-Cysteine residue in the active center of protease through the key chemical groups in its molecule. This kind of combination is strong and specific, just like a "molecular lock" to lock the blade of this "scissors" firmly, making it completely lose its cutting function. This combination is reversible under certain conditions.
4. Blocking the replication chain: Once the 3CL protease is inhibited, the virus polyprotein cannot be processed correctly, resulting in the failure to form a functional replicase complex. Therefore, the RNA genome replication of the virus was completely interrupted, and new virus particles could not be produced.
To sum up, Nirmatrelvir API powder didn't directly kill the virus or prevent the virus from entering the cell, but played the role of a "special agent", sneaked into the core factory of virus replication, and accurately destroyed its most critical production tool (3CL protease), thus "starving" the inhibitory function of virus replication from the root.This is also the fundamental difference between it and other antiviral products that act on viral RNA polymerase or enter the cell process.
Product Specification
| Items | Specifications | Results |
|
Appearance |
white to off-white crystalline powder | Complies |
| Assay (HPLC) | ≥98.0% | 99.58% |
| Water Content | ≤ 0.50% | 0.26% |
|
Heavy Metals |
≤10ppm |
<10ppm |
|
Microbial Limit |
≤20ppm |
<20ppm |
| Yeast &Mold | ≤50cfu/g | <10cfu/g |
| Coliforms | ≤3cfu/g | <3cfu/g |
| E.Coli | Negative/10g | Negative |
| Salmonella | Negative/25g | Negative |
| S.aureus | Negative/25g | Negative |
| Conclusion: The test results are conformed to the in-house specification | ||
How and where to buy Nirmatrelvir API powder wholesale ?
You can trust us completely because we have a good record in selling legal education drugs. Over the years, we have reached Many orders cooperation between Europe and America, which is safe and fast. Have safeguard.
Reasons for choosing us: reliable strength supply, high quality and stable storage, worry-free supply and timely delivery after sale.
Send your Inquiry for more details , Click email: sales7@faithfulbio.com Now.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details , Click email : sales7@faithfulbio.com Now.
FAQ:
Q1:Is your supply chain traceable and how to ensure quality consistency?
A1:Yes. We have a full traceability system from starting materials, intermediates to finished products. Each batch of products has a unique batch number, and the quality strictly implements international standards. We can provide COA and other information to ensure that each batch of products meets the agreed quality and purity standards.
Q2:What are the requirements for packaging and storage conditions? How to ensure transportation safety?
A2:The standard packaging is a sealed aluminum bag lined with double polyethylene bags, which is placed in a moisture-proof plastic bucket. It must be stored in dark, airtight and dry conditions, and the recommended temperature is 2-8 C (long-term) or below 25°C (short-term). Transportation is usually by air. We will provide tracking information, and ensure the chemical stability of products during transportation.
Q3: Does your company offer large discounts ?
A3:Sure, Our price fluctuates according to the purchase quantity. The more purchases, the more advantages the unit price has. Please contact our professional by email, provide your specific quantity and delivery address, and we will prepare an accurate quotation for you.
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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