What is estradiol ?
Estradiol is a steroid hormone, which is mainly secreted by ovarian follicles, corpus luteum and placenta during pregnancy. It is the most important and biologically active hormone in estrogen.
It has two types, α and β, which were extracted from pregnant horse urine by Wintersteiner et al. 1935, and can also be obtained from pregnant woman urine, human placenta, pig ovary and so on. It also exists in the testis or urine of male horses. Because it has a strong sex hormone effect, it is considered that its ester is actually the most important sex hormone secreted by the ovary.
estradiol powder bulk is a white or milky white or amorphous powder, which is insoluble in water. Estradiol is an intermediate between estradiol valerate and estradiol benzoate.
| Product name |
estradiol powder bulk |
| CAS | 50-28-2 |
| structural formula | C18H24O2 |
| molecular weight | 272.39 |
| EINECS | 200-023-8 |
| melting point | 178-179 °C(lit.) |
| boiling point | 355.44°C (rough estimate) |
| refractive index | 80.4 ° (C=1, Dioxane) |
| density | 1.0708 (rough estimate) |
| Storage condition | room temp |
What is the use and efficacy of estradiol ?
estradiol powder bulk can be used for treating uterine functional bleeding, primary amenorrhea, climacteric syndrome and prostate cancer. Estradiol can promote and regulate the normal growth of female sexual organs and secondary sexual characteristics, promote the maturity and growth of mammary ducts, and help to locate. Estradiol can also be used in biochemical research.
It is secreted by granulosa cells in ovarian follicles. Its metabolites are estrone and estriol. Containing 18 carbon atoms. Its target organs are uterus, vagina, fallopian tube and pituitary gland. estradiol Can be used as an estrogen therapeutic agent absorbed through the skin. Supplementing the deficiency of 17-β estradiol secreted by female ovaries. Estrogen can promote cells to synthesize DNA, RNA and various protein in corresponding tissues.
Estradiol is mainly used to supplement estrogen in the body, relieve menopausal symptoms, improve osteoporosis, hypoestrogenia and assist fertility treatment.
1. Supplement estrogen
β-Estradiol can directly supplement estrogen deficiency caused by ovarian dysfunction or loss. For example, after menopause, women's ovarian function declines, and the level of estrogen in the body drops, which can maintain physiological function through exogenous supplementation.
2. Relieve menopausal symptoms
It can regulate hypothalamus-thermoregulatory center and reduce symptoms such as hot flashes and night sweats caused by vasodilation. Clinical data show that 70% patients' related symptoms have been improved.
3. Improve osteoporosis
β-Estradiol helps to maintain bone density by promoting osteoblast activity and inhibiting osteoclast absorption. For postmenopausal women, the risk of osteoporotic fracture can be reduced by 30%-50%.
4, contribute to estrogen.
estradiol powder bulk is suitable for primary ovarian insufficiency, surgical castration, etc. By maintaining serum estradiol in the range of 30-100pg/ml, the problems of genital atrophy and menstrual disorder can be improved.
5. Assisted fertility treatment
In assisted reproductive technology, estradiol is often used to promote endometrial hyperplasia and create an environment suitable for embryo implantation.
Product Specification
| Items | Specifications | Results | ||
| Appearance | white crystalline powder | Complies | ||
| Assay | 98%-101% | 99.26% | ||
| Loss on Drying | ≤5.0% | 0.08% | ||
| Residue on Ignition | ≤0.1% | 0.05% | ||
| Heavy metals | ≤10ppm | 3.95ppm | ||
| As | ≤1ppm | ≤1ppm | ||
| Pb | ≤1ppm | ≤1ppm | ||
| Cd | ≤1ppm | ≤1ppm | ||
| Hg | ≤0.1ppm | ≤0.1ppm | ||
| Total Plate count | ≤1000CFU/g | <10CFU/g | ||
| Yeast &Mould | ≤100CFU/g | <10CFU/g | ||
| Escherichia Coli | Negative | Negative | ||
| P.aeruginosa | Negative | Negative | ||
| S.aureus | Negative | Negative | ||
| Salmonella | Negative | Negative | ||
| Conclusion: The test results are conformed to the in-house specification | ||||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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