99% Powder GS-441524 CAS 1191237-69-0
Product Name:GS-441524
CAS NO.:1191237-69-0
Molecular Formula:C12H13N5O4
EINECS.NO:200-001-8
Synonym:GS-441524;EVO 984;EVO984;EVO 984;GS441524;GS 441524;GS-441524;
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
GS-5734 is a small molecule RNA-dependent RNA polymerase (RdRp) inhibitor, and its scientific name is nucleoside triphosphate competitive inhibitor, which shows strong antiviral activity against many RNA viruses. It can also inhibit the replication of several different types of RNA viruses. 99% Powder GS-441524 is off-white solid powder. If it is not used for a long time, it can be stored in DMSO solution at-20 C for up to one month.
| Molecular formula |
|
|
|
Item |
Standard |
Test Results |
|
Description |
White Crystal Powder |
Complies |
|
Assay |
≥99% |
99.12% |
|
Ash |
≤ 5.0% |
2.85% |
|
Loss on Drying |
≤ 5.0% |
2.82% |
|
Heavy Metal |
≤ 10.0 mg/kg |
Complies |
|
Pb |
≤ 2.0 mg/kg |
Complies |
|
As |
≤ 1.0 mg/kg |
Complies |
|
Hg |
≤ 0.1 mg/kg |
Complies |
|
Residue of Pesticide |
Negative |
Negative |
|
Total Plate Count |
≤ 1000cfu/g |
Complies |
|
Yeast&Mold |
≤ 100cfu/g |
Complies |
|
E.coil |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
| Conclusion： |
Conform with enterprise specification . |
What is GS-441524?
Feline Infectious Peritonitis is a chronic, progressive, and fatal infectious disease caused by feline infectious peritonitis virus, characterized by peritonitis, accumulation of large amounts of ascites, and high mortality rate. 99% Powder GS-441524 is an inhibitor of ribonucleotide analogues, which serves as a specific drug for treating FIP caused by feline coronavirus. Its mechanism mainly involves acting as a "disguiser" to "deceive" the virus's RNA dependent RNA polymerase (RdRp) into binding to it, thereby interrupting RNA virus replication and relying on autoimmunity to defeat the virus. Originally developed for Ebola virus, it is also a precursor drug of remdesivir (GS-5734). remdesivir is a drug derived from phosphorylation of GS-441524.
What are the differences between this product and GC376?
GS-441524 is a small molecule, scientific name triphosphate nucleoside competitive inhibitor, which exhibits strong antiviral activity against many RNA viruses. It can inhibit the replication of several different types of RNA viruses, but currently the most widely used is for the treatment of FIP, and it has better efficacy compared to GC376, which used to treat feline transmission in the past.
(1)The mechanism of action is different: 99% Powder GS-441524 blocks virus replication in the gene synthesis stage of cat infectious peritonitis virus replication, while GC376 acts on 3C protease of cat infectious peritonitis virus and blocks virus protein synthesis;(2) In terms of the mechanism of virus replication, Remdesivir acts on the gene synthesis stage in the early stage of virus replication, while GC376 acts on the protein synthesis stage in the late stage of virus replication;(3)Large difference in cure rate: according to relevant reports, 99% GS-441524 Powder was used continuously for two weeks under the condition of artificial inoculation of the virus, and the cure rate was 100%. 26 cats with natural infection received one or more rounds of treatment. After 10-13 months, 24 cats were still healthy, and the overall cure rate reached 92%, while GC376 was used continuously for 20 days under the condition of artificial inoculation of the virus, The cure rate can reach 90%, but under natural infection conditions, the cure rate is only 50%
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide GS-441524 Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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