Tetrahydropiperine CAS 23434-88-0

How to extract Tetrahydropiperine?

6. Purification: Use high-performance liquid chromatography (HPLC) and other methods to purify the concentrated solution, in order to separate high-purity tetrahydropiperine.
Multiple column chromatography or other separation techniques may be required during the purification process to ensure that the purity of the product reaches over 98%.
7. Drying: Dry the purified tetrahydropiperine to obtain the final solid product. The drying method can be freeze drying or spray drying.

Product Specification

Conclusion：Conform with enterprise specification .

Where is Tetrahydropiperine usually used?

Tetrahydropiperine is a chemical substance that is a cyclohexyl analogue of piperine, derived from Piper longum. Some common uses of it:
1. Inhibition of cytochrome P450 (CYP) isoform CYP1A1: Tetrahydropiperine can inhibit cytochrome P450 (CYP) isoform CYP1A1/aryl hydrocarbon hydroxylase (AHH), with a half maximal inhibitory concentration (IC50) of 23 micromoles (μ M).
2. Promote the absorption of functional ingredients: Tetrahydropiperine can be used to promote the absorption of functional ingredients, such as in spot whitening and acne products, it can improve the absorption efficiency of vitamins, polyphenols, alkaloids and other ingredients.
3. Whitening and heating effects: As a stable, safe and non irritating ingredient, tetrahydropiperine is currently the only natural substance extracted and isolated from plants with strong penetration promoting effects. It not only promotes whitening, but also has a heating effect that can raise the temperature of the skin, thereby improving blood circulation and metabolism.
In summary, tetrahydropiperine has broad application prospects in the fields of medicine and cosmetics.

What are the effects of Tetrahydropiperine ?

Tetrahydropiperine is a natural aromatic pentanamide isolated from Piper longum, which has various biological activities and potential pharmacological effects. Here are its main effects:
1. Anti inflammatory effect: Tetrahydropiperine can inhibit nuclear translocation and phosphorylation of MAPKs such as ERK, JNK, p38, thereby reducing the production of pro-inflammatory cytokines such as TNF - α, IL-6, and nitric oxide (NO).
2. Anti apoptotic effect: By activating pathways to inhibit excessive autophagy, it protects neurons from oxidative damage and demonstrates its anti apoptotic effect.
3. Neuroprotective effect: Due to its anti-inflammatory and anti apoptotic effects, tetrahydropiperine has shown neuroprotective effects in research on neurological diseases, such as ischemic stroke.
4. Anti cancer effect: Tetrahydropiperine exhibits inhibitory effects on certain cancers by inhibiting cytochrome P450 (CYP) isoform CYP1A1/aryl hydrocarbon hydroxylase (AHH).
5. Other potential effects: Tetrahydropiperine may also have therapeutic effects on epilepsy, pain relief, and insect control.
It should be noted that these effects are mainly based on in vitro studies and animal experiments, and the exact efficacy and safety of tetrahydropiperine in humans still need further clinical trials to confirm.