Huperzine A Powder CAS 102518-79-6

HupA is a natural plant alkaloid isolated from Huperzia serrata, a Huperdaceae family plant. It is a powerful, reversible and highly selective second-generation acetylcholinesterase inhibitor. The research shows that high-quality Huperzine A powder can effectively prevent neurasthenia, restore cranial nerve function and activate neurotransmitters in middle-aged and elderly people, and it is a new product for treating benign memory impairment at present. In addition, It can attenuate the toxicity of β -amyloid protein, prevent glutamate-induced neurotoxicity and resist free radicals.

What are the related studies on Anticholinesterase?

According to the latest scientific literature, free acetylcholine in the body plays an important role in neural stimulation, memory and learning, as well as excitation. 9000-81-1 Anticholinesterase is an enzyme in the brain that breaks down the neurotransmitter acetylcholine, responsible for a large number of neuronal synaptic functions and neural excitation in the central nervous system. One acetylcholinesterase molecule can reduce the function of approximately 25000 acetylcholine molecules. The latest research has found that Alzheimer's patients usually lack sufficient amounts of acetylcholine. Scientists previously hoped to achieve this goal by consuming more acetylcholine, but excessive acetylcholine often leads to muscle paralysis and suffocation death. Recently, scientists have chosen to reduce acetylcholinesterase levels to release acetylcholine and activate more neurons, and have made good progress.

Huperzine A is a representative second-generation acetylcholinesterase inhibitor. Characterized by strong efficacy, reversibility, and high selectivity. Pure (-)-Huperzine A powder is a slightly yellow to white crystalline substance with small molecules and high lipid solubility. Its free HupA can penetrate the blood-brain barrier well and enter the central nervous system, mainly distributed in the frontal lobe, temporal lobe, hippocampus and other brain areas closely related to learning and memory. At low doses, It has a strong inhibitory effect on acetylcholinesterase (AchE), significantly increasing the content of Ach in the synaptic cleft of the distribution area, thereby enhancing neuronal excitation conduction, strengthening the excitatory effect of learning and memory brain areas, improving cognitive function, enhancing memory retention and promoting memory reproduction. This is also the most successfully developed natural raw material for treating Alzheimer's disease (senile dementia) in China.

What are the studies on the neuroprotective effect of Huperzine A?

Hup A(Huperzine A Powder) not only has obvious cholinesterase inhibition, but also has extensive neuroprotective effects. Its protective effect also plays an important role in the treatment of AD and the protection against neurotoxic substances.

1 anti-inflammatory effect and its protection on neural stem cells in rats
The ratio of pro-apoptosis and anti-apoptosis proteins in the Bcl-2 protein family determines whether a cell undergoes apoptosis after being stimulated by apoptosis signals. When the value of Bcl-2/Bax decreased, Bax formed homodimer and induced apoptosis. However, when the value of Bcl-2/Bax increases, Bax and Bcl-2 form heterodimers, which realizes the function of Bcl-2 in inhibiting apoptosis. In rat experiments, researchers found that the expression of Bcl-2 and Bax in neural stem cells was the highest in each group, while the value of Bcl-2/Bax was the lowest in each group. After Hup A pretreated microglia, the secretion of inflammatory factors was decreased by liquid chip detection, and the value of Bcl-2/Bax was significantly higher than that of Aβ group, which inhibited the apoptosis of neural stem cells. The results of Western blotting and flow cytometry showed that Hup A could inhibit the apoptosis of neural stem cells.

2 Anti-organophosphorus neurotoxicity effect
The main mechanism of Hup A against organophosphate poisoning is that Hup A binds to acetylcholinesterase reversibly before administration in advance, thus preventing the irreversible combination of organophosphorus compounds with acetylcholinesterase. Compared with other reversible cholinesterase inhibitors such as pyridostigmine bromide, Hup A has two advantages: on the one hand, Hup A can pass through the blood-brain barrier, thus protecting acetylcholinesterase in the brain. On the other hand, butyrylcholinesterase and carboxylesterase may be endogenous organic phosphorus scavengers, and Hup A can selectively inhibit acetylcholinesterase in plasma erythrocytes, but has no inhibitory effect on butyrylcholinesterase, so the selectivity of Hup A is helpful for the prevention of organophosphorus poisoning.

3 Anti-glutamate toxicity
Glutamate is an agonist of N- methyl -D- aspartic acid (NMDA) receptor. Excited NMDA receptor can increase the influx of calcium ions into neurons, and high concentration of calcium ions will lead to cell death. Hup A can reduce the toxicity of glutamate to nerve cells and improve the cell survival rate, especially for mature neurons, because there are more NMDA receptors in mature neurons. The mechanism of antagonizing glutamate may be that after NMDA receptor is excited, Hup A blocks the downstream part of its signal transduction pathway, thus preventing cell death caused by glutamate. In addition, the protective effect of Hup A on nerve cells may also be mediated by glutamate receptor.

4 pairs of antioxidant stress
Hup A can protect neurons from the toxicity of β -amyloid protein and increase the production of superoxide dismutase (SOD). Cultured rat primary cortical cells in vitro were incubated under the condition of Aβ 25-35 (amino acid residues 25-35 of β -amyloid fragment), and apoptosis, cell viability decreased obviously, morphological changes of neurons and their DNA fragments were observed. Administration of Hup A in advance can obviously improve the cell survival rate and prevent cell nucleus fragmentation. The mechanism is that Hup A inhibits the formation of ROS reactive oxygen species and the activity of caspase-3.

5 Inhibit the neurotoxicity of NO.
Studies have shown that NO can inhibit the growth of human neuroblastoma SK-N-SH cells and induce apoptosis. Hup A, ginkgolides A and B can block the apoptosis and growth inhibition of sodium nitroprusside (NO donor) on SK-N-SH cells. In addition, Hup A and ginkgolides A and B can also inhibit the production of NO in mouse glial cells and human and mouse astrocytes.

What should we pay attention to when using Huperzine A?

In the known literature, it is found that it is safe to use huperzine A raw powder in a short period of time (6 months). However, possible side effects or adverse reactions include: anxiety, nausea, diarrhea, vomiting, dry mouth, constipation, sweating, blurred vision, slurred speech, hyperactivity, stuffy nose, fainting, loss of appetite, convulsions, cramps, abnormal heart rhythm, increased saliva and urine, uncontrollable urination, high blood pressure, dizziness and insomnia (especially in the case of large dosage).

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Huperzine A Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: huperzine a powder cas 102518-79-6, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China