What is Mangiferin ?
Mango, a plant of Rhus vernicifera, recorded in "Kaibao Materia Medica" that it can quench thirst by eating, and treat thirst by decocting leaves in soup. Compendium of Materia Medica records that it is the best fruit. "Compendium of Materia Medica" records that mango can benefit stomach qi and stop vomiting and dizziness. It is found that mangiferin existing in branches, leaves and bark of mango has a wide range of pharmacological effects, such as anti-inflammatory, antipyretic and analgesic, antibacterial, immunomodulation, hypoglycemic and antioxidant.
Mangiferin, also known as Guanzhimaning, is a carboketone glycoside of tetrahydroxypyrone, which belongs to a flavonoid compound of diphenyl pyrone. Mangiferin mainly comes from the dried rhizome of Anemarrhena asphodeloides, the leaves, fruits and bark of almond and mango, and the five-story roots of Hainan, a five-story dragon plant of Pteridaceae. Mangiferin powder has many pharmacological activities such as relieving cough, relieving asthma, eliminating phlegm, resisting inflammation, relieving pain, protecting liver and gallbladder, resisting lipid peroxidation, resisting cancer, resisting diabetes, resisting bacteria and viruses.
| Product name |
Mangiferin |
| CAS | 4773-96-0 |
| structural formula | C19H18O11 |
| molecular weight | 422.34 |
| EINECS | 624-757-7 |
| melting point | 269-270°C |
| boiling point | 842.7±65.0 °C(Predicted) |
| Acidity coefficient (pKa) | 6.09±0.20(Predicted) |
| density | 1.843±0.06 g/cm3(Predicted) |
| Storage condition | 2-8°C,keep dry |
How is Mangiferin powder extracted ?
1. Organic solvent extraction process
Using more than 90% ethanol as extraction solvent, mangiferin with high purity can be extracted from mango leaves.
2. Water-based solvent extraction process
Mangiferin was extracted from mango leaves with weak alkaline water as extraction solvent, and the extract was eluted by D101 column macroporous resin and decolorized by D301 column. The extraction process of high purity mangiferin is suitable for industrial production.
3. Enzymatic extraction process
Mangiferin powder was extracted from mango leaves by cellulase. The experimental conditions were as follows: enzymolysis PH was 5.0, temperature was 55℃ and time was 2h.
4. Ultrasonic-assisted extraction process
Ultrasonic-assisted extraction process has the advantages of simplicity, short time consumption and energy saving, and has a good development and application prospect.
What are the effects and functions of Mangiferin powder ?
2. Anti-tumor effect
The occurrence of leukemia is related to the disorder of cell cycle regulation, which is closely related to the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia. The occurrence of leukemia is related to the disorder of cell cycle regulation, which is closely related to the expression of telomerase activity. Therefore, the study of abnormal regulation of telomerase and cell cycle has become a new direction to explore the occurrence and treatment of leukemia.
3. Neuroprotective effect
Mangiferin powder with polyphenol structure can protect neurons by reducing Ca2+ influx and oxidative stress, thus reducing cell death caused by glutamate in neurons.
4. Antiviral effect
It has anti-herpes simplex virus type I (HSV-I) effect in vitro, and the plaque reduction rate is 56.8%. Its antiviral effect is attributed to its ability to inhibit intracellular virus replication.
5. Antipyretic effect
It has a good antipyretic effect on the experimental animal model of fever caused by endotoxin, and it is positively correlated with the dose, and has a good protective effect on thermal damage.
6. Analgesic effect
It has significant analgesic effect on pain induced by acetic acid and hot plate test. Compared with naloxone hydrochloride, it is found that mangiferin-induced analgesia is not dependent on opioid receptors, and its analgesic effect is significant, with little influence on peripheral nerves.
7. Anti-parasitic effect
Mangiferin powder has obvious inhibitory effect on Cryptosporidium parvum in young mice. Effects of mangiferin on mice infected with nematodes and Trichinella spiralis.
8. Anti-diabetic effect
Studies have shown that it can reduce the blood sugar concentration of KK-Ay mice, an animal model of spontaneous diabetes, and the serum insulin level also tends to decrease. Fruit glycoside and its glucoside may show anti-diabetic activity through insulin sensitization.
9. Liver-protecting and gallbladder-benefiting effects
For the protection of liver, mangiferin can stabilize lysosomal membrane and directly inhibit the activity of lysosomal acid phosphatase. It also has obvious cholagogic effect.
10. Effects on the central nervous system Mangiferin has obvious central nervous system excitation effect.
Mangiferin has the function of scavenging lipid peroxide in brain tissue, reducing the damage of lipid peroxide to neurons, thus protecting the normal function of neurons.
11. Effects on respiratory system
It has glucocorticoid-like anti-inflammatory effect and can reduce capillary permeability, and its anti-inflammatory reaction rate is 38%.
Because of the anti-inflammatory effect of Mangiferin powder, it has a certain effect on bronchial asthma,
which is as follows: ① it can significantly prolong the induced asthma time compared with asthma group; ② The degree of asthma was reduced, and the incidence of convulsion was significantly lower than that of asthma group; ③ The emphysema was obviously relieved, the infiltration of inflammatory cells in the lung was significantly less than that in the asthma group, and the lung/body weight ratio was significantly lower than that in the asthma group, which was close to that in the dexamethasone group. At the same time, mangiferin can reduce the levels of serum NO and endothelin -1(ET-1) in alveolar lavage fluid, and play a preventive role in asthma attack.
Product Specification
| Items | Specifications | Results | ||
|
Appearance |
Light Yellow Powder | Light Yellow Powder | ||
| Assay | 98%-101% | 98.82% | ||
| Particle Size | 100% through 80 Mesh | Complies | ||
| Loss on Drying | < 5.0% | 0.15% | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies | ||
| Pb | ≤ 2.0 mg/kg | Complies | ||
| As | ≤ 1.0 mg/kg | Complies | ||
| Hg | ≤ 0.1 mg/kg | Complies | ||
|
Total Plate Count |
<1000cfu/g |
90cfu/g |
||
|
Yeast & Mold |
<100cfu/g |
18cfu/g |
||
|
E. Coli |
Negative |
Absent |
||
|
S. Aureus |
Negative |
Absent |
||
|
Saimonella |
Negative |
Absent |
||
|
Pesticides |
Negative |
Absent |
||
| Conclusion: The test results are conformed to the in-house specification | ||||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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