Phaseolin CAS 13401-40-6

Phaseolin is an isoflavone plant antitoxin, which can be isolated from kidney beans. Phaseolin is toxic to soybean hypocotyl and endoderm cells, and can cause complete lysis of sheep red blood cells.In addition, It also has a variety of pharmacological activities, such as inhibiting α-amylase, estrogen activity, potential anti-tumor effect and so on.

What is the pharmacological activity of Phaseolin?

1. Inhibition of α -amylase
The practice of losing weight with α -amylase inhibitors was very popular in the 1980s. Based on the scientific research at that time, there were two types of α-amylase. Among them, salivary amylase is a key one. It works when people start chewing food, and it remains partially active after food is swallowed. Most of these amylases are completely decomposed by trypsin in the small intestine and fully absorbed by the body. However, many plants produce α -amylase inhibitors, which is the evolutionary result of plants protecting themselves from insects. These inhibitors are divided into three types. Among them, Phaseolin was one of the first ones to be isolated. Studies have found that it is a kind of protein associated with a sugar called Glycoprotein. This α -amylase inhibitor can effectively resist animal α-amylase, but it has no effect on corresponding microorganisms or plant enzymes.
In the 21st century, with the rise of low-carbohydrate diet, people began to be interested in the second metabolites of these plants again. One of the reasons for this phenomenon is the improvement of purification in protein. At present, the raw powder of higher purity Phaseolin is obtained by inducer, so as to get rid of the low purity Phaseolin obtained by white kidney beans in 1970s. There are many suggestions for reducing weight of phaseolin. It is believed that it can reduce the starch decomposition rate of digestive tract, so it can reduce the absorption of raw sugar in small intestine. Some research institutions also believe that it will lead to a decrease in insulin release after eating.

2. Estrogen activity
Researchers used Aspergillus sojae as an inducer to induce kidney bean to produce phaseolin. The effects of phaseolin on the proliferation of Mcf-7 cells and HEek-293 cells were detected by ERE luciferase. The binding affinity analysis with estrogen receptor (ER) proved that phaseolin has estrogenic activity and can be used as a functional food ingredient for research and development.

3. Potential anti-tumor activity
Researchers isolated two kinds of pteridin flavonoids from Erythrina addisoniae, namely, Phaseolin and Neorautenol, which have inhibitory effects on the growth of liver cancer cell H4IIE. Both of them can reduce the activity of ERK, which is a mitogen-activated protein kinase, which is related to cell proliferation. In addition, related studies also show that phaseolin has potential anti-tumor active substances and is likely to become a new source of anti-tumor drugs.

Why do you say that Phaseolin needs to be obtained under stimulation?

Phaseolin is a secondary metabolite of kidney bean induced by external stimuli (biological and abiotic factors), and it is a plant defender. Studies have shown that red kidney beans and mung beans can produce plant antitoxins when they are treated with biological or abiotic inducers, such as insect bites, microorganisms and chemical substances, which have good antifungal activities, including Phaseolin and kievitone. At the same time, it was found that in addition to inducers, damaged or infected beans could also be detected to contain low concentrations of phytoantitoxin. However, studies have shown that kidney beans do not produce phaseolin when they are not subjected to external pressure or external stimulation.

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