What is Liquiritigenin powder?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Liquiritigenin powder is a natural flavanone flavonoid active substance isolated from licorice root, with the chemical code CAS 578-86-9 and the molecular formula C₁₅H₁₂O₄. In its pure state, it is a crystalline solid with weak water solubility. It exists naturally and stably in licorice raw materials and is a core marker active component of licorice extract. This substance possesses a unique molecular structure that can specifically act on endogenous estrogen-related receptor subtypes in the human body, exhibiting affinity only for β-receptors. It does not impose additional proliferative burden on breast or uterine tissues, making it a mild and affinity-based active ingredient derived from natural plants. Simultaneously, it can activate antioxidant signaling pathways in the body, enhance the activity of endogenous antioxidants, inhibit the transduction of various pro-inflammatory signals within the body, reduce the production of various inflammatory factors, and alleviate discomfort caused by oxidative stress in the skin and organs.
Application of Liquiritigenin powder
Widely used in skin care, it can act on enzymes related to pigment production, soothe redness and fragility, and brighten skin tone. It is often added to repairing and brightening skin care formulas. In the field of natural dietary ingredients, it serves as a core quality control indicator for licorice extract. When combined with glycosides such as glycyrrhizin, it is more easily decomposed and absorbed by the human intestinal environment. Currently, it is also widely used as a laboratory standard reference, serving scenarios such as plant extract testing and basic research on natural active substances. Basic research on bone health, vascular endothelial care, and nerve soothing is continuously advancing. Relying on its natural and gentle properties, it is suitable for various commercial applications, including skin care ingredients, plant extract ingredients, and scientific research standards.
COA
| Test Item | Specification | Test Result |
| Appearance | Off-white crystalline powder | Off-white crystalline powder |
| Purity(HPLC) | ≥98.0% | 98.62% |
| Melting Point | 206℃~208℃ | 207.1℃ |
| Loss on Drying | ≤0.50% | 0.21% |
| Residue on Ignition | ≤0.10% | 0.06% |
| Heavy Metals(Total) | ≤10 ppm | <5 ppm |
| Lead(Pb) | ≤2 ppm | <0.5 ppm |
| Arsenic(As) | ≤2 ppm | <0.5 ppm |
| Cadmium(Cd) | ≤1 ppm | <0.2 ppm |
| Mercury (Hg) | ≤0.1 ppm | <0.05 ppm |
| Conclusion | Conform with enterprise specification | |
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Density: 1.386±0.06 g/cm³ (Predicted)
Boiling Point: 529.5±50.0 °C (Predicted)
Melting Point: 206-208ºC
Molecular Formula: C15H12O4
Molecular Weight: 256.25
Flash Point: 207℃
Exact Mass: 256.073547 g
PSA: 66.76000
LogP: 2.76
Mechanism of action of LIQUIRITIGENIN
Selectively binds to estrogen β receptors. Its molecular structure specifically binds to human ERβ receptors, exhibiting almost no binding ability to ERα receptors. It gently regulates receptor-related signal transduction, gently maintaining homeostasis in bone, blood vessels, and nerve-related tissues, without stimulating excessive proliferation of breast and endometrial cells.
Activates endogenous antioxidant pathways. It upregulates the activity of the body's Nrf2 signaling pathway, promoting the production of various endogenous antioxidants, neutralizing oxidative reactive substances produced by the environment and metabolism, reducing cellular oxidative damage, and maintaining normal cellular physiological states.
Inhibits inflammation-related signal transduction. It blocks the activation of the NF-κB signaling pathway, reducing the release of various pro-inflammatory signaling molecules, lowering intercellular inflammatory signal transmission, and alleviating redness and discomfort in the skin and internal organs caused by stress.
Regulates the activity of skin pigmentation-related enzymes. It gently inhibits tyrosinase activity, slowing down the rate of skin pigmentation granule production, evening out skin tone; simultaneously soothing skin sensitivity signals and reducing skin redness caused by external stimuli.
Protecting the state of vascular endothelial cells: reducing oxidative stress damage to vascular endothelial cells, balancing the secretion of relevant factors within blood vessels, maintaining the smoothness and integrity of the vascular endothelium, and helping to maintain the normal physiological state of blood vessels.
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Our Factory
Package
Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What is Liquiditigenin?
Liquiritigenin is a natural flavanone flavonoid extracted and isolated from the root of licorice. Its CAS number is 578-86-9, and its molecular formula is C₁₅H₁₂O₄. In its pure form, it is a white crystalline powder and is the signature core active component of licorice extract.
02. What are the common purity grades of Liquiditigenin available on the market?
The mainstream grades are HPLC 98% purity and 99% high purity. 98% is mostly used as a cosmetic raw material; 99% high purity products are specifically for laboratory testing and academic research.
03. How should Liquiditigenin powder be stored?
Liquiritigenin powder should be stored in a sealed package in a cool, dry, and dark environment, away from high temperatures and strong light, to ensure long-term stability and prevent changes in its properties.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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