What is Ligustilide?
Ligustilide, Artemisia annua lactone is a natural product extracted from the roots of Angelica sinensis, a plant in the Umbelliferae family.
Ligustilide is the main active ingredient in the volatile oil of Angelica sinensis, which has various potential pharmacological activities such as anti platelet aggregation, vasodilation, anti-inflammatory, antioxidant, and anti-tumor. It can be extracted from the roots of Angelica sinensis by steam distillation and has been widely used in pharmacological and biological research.
| Product name | Ligustilide |
| CAS | 4431-01-0 |
| Molecular formula | C12H14O2 |
| Molecular weight | 190.24 |
| form | liquid |
| Storage condition | -20°C, protect from light, stored under nitrogen |
| stability | photosensitive |
| Solubility | DMSO: 100 mg/mL (525.65 mM; ultrasound required) |
| Appearance | Colorless to light yellow |
| Boiling point | 377.9±11.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
How to extract Ligustilide?
The following is an efficient extraction and purification method for ligustilide in Ligusticum chuanxiong:
After crushing the dried medicinal herbs of Chuanxiong, pass them through a 20-60 mesh sieve to obtain Chuanxiong powder.
Soak the above Chuanqiong powder in an extraction solvent containing petroleum ether and ethanol.
Extracting ligustilide from Ligusticum chuanxiong using column extraction method from the soaked Chuanqiong powder can obtain an extract containing ligustilide.
Add the extracted solution obtained above to water for extraction, and then collect the petroleum ether phase for vacuum rotary evaporation concentration to obtain a concentrate of ligustilide.
Using silica gel column chromatography with petroleum ether and ethyl acetate as elution solvents for isocratic elution, the concentrated ligustilide was separated and purified to obtain the purified elution solution of ligustilide from Ligusticum chuanxiong.
The purified eluent of ligustilide was concentrated by vacuum rotary evaporation to obtain the pure product of ligustilide.
The above is the efficient extraction and purification method of Ligustilide from Ligusticum chuanxiong.
Product Specification
|
Items |
Specification |
Results |
||
|
Appearance |
yellow liquid |
Conforms |
||
|
Loss on drying |
≤2.0% |
≤2.0% | ||
|
HPLC |
NA |
99.02% | ||
|
Mass Spectrum |
Conforms |
Conforms |
||
Conclusion：Conform with enterprise specification .
Where is Ligustilide usually used?
Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong, with multiple pharmacological effects. Here are some of the main uses of Ligustilide:
1. Neuroprotective effect: Ligustilide can protect neurons from damage and may have potential applications in the treatment of neurological diseases such as Alzheimer's disease and Parkinson's disease.
2. Anti cancer effect: Studies have shown that Ligustilide has the ability to inhibit cancer cell proliferation and induce cancer cell apoptosis, which may become a new strategy for cancer treatment.
3. Anti inflammatory effect: It can alleviate inflammatory reactions and may be used to treat various inflammatory diseases.
4. Vasodilatory effect: It also exhibits vasodilatory effects, which may help improve blood circulation and treat related diseases.
5. Protecting the kidneys: In the renal ischemia-reperfusion injury model, Ligustilide exhibits a protective effect on mitochondrial function, reduces oxidative stress, and suggests its potential in the treatment of kidney diseases.
6. Regulating energy metabolism: Ligustilide can treat obesity by regulating the expression of lipid metabolism related proteins.
7. Treatment of alcoholic liver steatosis: It has shown potential in treating alcoholic liver steatosis by targeting RXFP1, inhibiting the activation of NLRP3 inflammasome and the formation of NET.
It should be noted that although Ligustilide exhibits a wide range of pharmacological activities, its clinical applications are still in the research stage, and many potential uses require further clinical trial validation. In addition, due to the instability of Ligustride in solution, it is recommended to use it immediately and prepare it immediately
What are the effects of Ligustilide?
Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong, with multiple biological activities and potential pharmacological effects. The following are the main benefits of ligustilide:
1. Neuroprotective effect: It can significantly improve cell survival rate, reduce glutamate induced apoptosis rate of PC12 cells, and reduce extracellular calcium ion accumulation, thereby protecting neurons.
2. Anti cancer effect: it can inhibit cancer cell proliferation and induce cancer cell apoptosis by downregulating Caspase-3 protein expression and upregulating Bcl-2/Bax ratio, demonstrating certain anti-cancer potential.
3. Anti inflammatory effect: Ligustilide has anti-inflammatory effects and can alleviate inflammatory reactions, which is related to its ability to downregulate the release of inflammatory mediators and activate inflammatory signaling pathways.
4. Vasodilatory effect: Ligustilide can dilate blood vessels and improve blood circulation, which is of great significance for the treatment of cardiovascular diseases.
4. Treatment of non-alcoholic fatty liver disease (NAFLD): (Z) - Ligustilide can inhibit the expression of FATP5 and DGAT, thereby suppressing the uptake and esterification of fatty acids in mice, demonstrating its potential for treating non-alcoholic fatty liver disease.
It should be noted that the above studies mainly focus on in vitro experiments and animal models, and further research is needed to confirm the actual effectiveness and safety of ligustilide in humans. In addition, due to individual differences and the possibility of drug interactions, it is recommended to consult a professional healthcare professional before using ligustilide.
How and where to buy ligustilide powder wholesale?
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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