what is Artesunate powder?
Artesunate powder Artesunate was developed in 1977.It is on the World Health Organization's List of Essential Medicines.It was approved for medical use in the United States in May 2020. It is in the class of medications known as artemisinins, which are derivatives from "qinghao," or sweet wormwood plant. Artesunate is a commonly used antiparasitic drug. It is a derivative of artemisinin with sesquiterpene lactone structure. Artesunate has stronger effect on Plasmodium than artemisinin and is also effective against chloroquine strain.
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Product name |
Artesunate |
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CAS |
88495-63-0 |
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Molecular formula |
C19H28O8 | |
|
Molecular weight |
384.42 | |
| EINECS | 618-170-5 | |
|
Appearance |
white crystalline powder |
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| Melting point | 132-135°C | |
| Density | 1.2076 (rough estimate) |
what are the uses of Artesunate powder?
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Artesunate powder has a strong killing effect on the asexual body of Plasmodium and can quickly control the outbreak of malaria It is a semi synthetic artemisinin derivative. It has been proved to be effective against parasites, such as liver flukes. It also shows cytotoxicity to different types of tumor cell lines. Acting on the electron transport chain, it produces local reactive oxygen species and causes the depolarization of mitochondrial membrane. It can inhibit the production of TNF induced pro-inflammatory cytokines by inhibiting NF - κ B and PI3 kinase/Akt signaling pathway in human rheumatoid arthritis fibroblast like synoviocytes. If you need it, pls click e-mail sales1@faithfulbio.com |
Product Specification
| Items | Specifications |
Result |
|
Appearance |
White crystalline powder |
White crystalline powder |
|
Odor & Tasted |
Characteristic |
Complies |
|
Loss on Drying(%) |
≤0.5 | 0.24 |
|
Ash(%) |
≤0.1 |
0.07 |
|
pH |
3.5-4.5 |
4.2 |
| Total impurity | ≤2.0% |
0.14% |
|
Assay |
≥98% |
98.3% |
|
Total Heavy Metal |
≤10mg/kg |
Complies |
|
Arsenic (As) |
≤2.0mg/kg |
Complies |
|
Cadmium (Cd) |
≤0.3mg/kg |
Complies |
|
Lead (Pb) |
≤0.5mg/kg |
Complies |
|
Mercury (Hg) |
≤0.1mg/kg |
Complies |
|
Ethanol |
≤0.5% |
Not detectable |
|
Total Bacterial |
≤1000cfu/g |
Complies |
|
Mold And Yeast |
≤100cfu/g |
Complies |
|
Colon Bacillus |
Negative |
Not detectable |
|
Salmonella |
Negative |
Not detectable |
|
Staphylococcus |
Negative |
Not detectable |
What are the Mechanism of action of Artesunate powder?
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|
Artesunate powder is metabolized to the active DHA. the endoperoxide bridge of DHA reacts with heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all erythrocytic stages. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase |
Is artesunate powder safe for pregnant women and children.
When given in the second or third trimesters of pregnancy, no artesunate-related adverse pregnancy outcomes have been reported.However, there is insufficient evidence regarding the safety of artesunate powder use in the first trimester of pregnancy. The WHO recommends that artesunate use for severe malaria in the first trimester should be based on the individual risks versus benefits. In absence of other viable treatment options, artesunate may be used
Artesunate is safe for use in children. Artesunate + sulfadoxine/pyrimethamine should be avoided in the newborns due to sulfadoxine/pyrmethamine effects on bilirubin.
How and where to buy artesunate powder?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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