What is Dihexa?
Dihexa Acetate is a novel synthetic peptide active pharmaceutical ingredient (API) of the angiotensin IV receptor agonist class, with the chemical formula C20H36N4O4·C2H4O2 and a molecular weight of 440.58 or 498.62. This product is a white to off-white powder and is a hexapeptide derivative with good blood-brain barrier penetration and high oral bioavailability, belonging to the innovative candidate compounds in the fields of cognitive enhancement and neuroprotection. Its core mechanism of action is to promote synapse formation and neuronal survival by activating hepatocyte growth factor receptors. Due to its significant potential for cognitive improvement and neuroregenerative capacity, this compound has received widespread attention in neuroscience and drug development in recent years.
What role does Dihexa play in cognitive impairment and neurodegenerative diseases?
Dihexa Acetate is primarily used in neuroscience research and drug development, with applications spanning multiple cutting-edge areas. In cognitive enhancement research, this compound is used to explore the molecular mechanisms that improve learning and memory functions, showing potential to reverse age-related cognitive decline, particularly in animal models. In research on treatment strategies for neurodegenerative diseases, Dihexa Acetate is used in preclinical studies of Alzheimer's disease, Parkinson's disease, and other conditions to evaluate its promoting effects on neuronal survival and synaptic plasticity.
In the field of nerve injury repair, this compound is studied for its potential to aid in the recovery of neurological function after traumatic brain injury and ischemic stroke. Furthermore, in pharmaceutical formulation development, this active pharmaceutical ingredient is a core component in the preparation of oral, injectable, and nasal formulations. It can also be formulated as hydrochloride monohydrate and diethyl acetate, and is widely used in innovative drug development and preclinical pharmacodynamic studies.
How to build a brain neurorepair pharmacological system using Dihexa acetate?
Dihexa acetate can amplify the binding efficiency of HGF and c-Met receptors in vivo with high affinity, activate downstream Akt and ERK cell survival signaling pathways, inhibit neuronal apoptosis, accelerate the generation of new synaptic structures, and remodel the brain's neural synaptic network structure. The acetate structure reduces the rate of degradation of the raw material by peptidases in vivo, improves oral absorption, facilitates its crossing of the blood-brain barrier, reduces oxidative stress and neuroinflammation in the brain, alleviates nerve damage caused by β-amyloid protein, and improves cognitive decline problems such as memory loss and slowed thinking. Dihexa acetate can be developed as a single-ingredient formulation or combined with other nootropic active ingredients for pharmacological intervention in the later stages of nerve damage repair and age-related cognitive decline.
MF of Dihexa acetate
Molecular Formula: C20H36N4O4·C2H4O2
Molecular Weight: 564.72
Melting Point: 209℃
Precision quality: 564.3313
Density: 1.11g/cm³
PH: 5.1～6.3
Product Specification
| Item | Specification | Result |
| Appearance | White to off‑white powder | Complies |
| Identification | IR/HPLC consistent with standard | Complies |
| Assay | 98.0%‑102.0% | 99.71% |
| Purity | ≥ 99.0% | 99.32% |
| Loss on Drying | ≤1.0% | 0.47% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Conclusion | Complies with enterprise standard | |
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FAQ：
Q1: What are the improvements in efficacy between Dihexa acetate and free Dihexa?
A1: Acetate modification optimizes water solubility, enhances resistance to enzymatic degradation, increases oral bioavailability, extends the duration of action in brain tissue, and ensures consistent and stable neural signal activation effects across batches.
Q2: What targeted pharmacological effects can Dihexa achieve on nerve cells?
A2: It can activate the HGF-c-Met pathway, reduce neuronal apoptosis, promote synaptic regeneration, alleviate brain inflammation, and improve cognitive decline caused by aging or brain injury.
Q3: How compatible is Dihexa acetate with other active ingredients?
A3: It has strong physicochemical compatibility and can be compounded with antioxidant and nootropic ingredients. It is suitable for formulation development in various dosage forms such as oral powders and tablets, and for new drug development formulation design.
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