Thymic serum factor Introduction
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Thymulin is a zinc-containing nine-peptide hormone naturally produced by thymic epithelial cells. Its biological activity depends on the participation of zinc ions. It is a crucial immunomodulator. Thymic serum factor is mainly applied in fields such as immunomodulation, anti-aging, and tumor immunity. CAS number: 63958-90-7; Molecular formula: C33H54N12O15; Molecular weight: 858.85; EINECS number: 236-855-3
What are the unique mechanisms of action of thymic serum factor?
The unique mechanism of action of Thymic Serum Factor is mainly reflected in its active structural characteristics and its extensive regulatory effects. It is synthesized by thymic epithelial cells and is a nine-peptide active substance that binds to zinc ions. This component has an important characteristic: its biological activity is inseparable from zinc ions. Only when it forms a stable complex with zinc can it be recognized and exert its function by immune cells. By relying on this metal ion synergy mode, it can precisely regulate immune responses and does not simply activate or deactivate immune functions.
As a mature immunomodulatory active peptide, the core function of Thymulin is to guide the differentiation and maturation of T lymphocytes. In addition, it can also target and regulate multiple inflammatory pathways, inhibit the activity of signaling pathways such as NF-κB and p38 MAPK, reduce the release of various pro-inflammatory factors, and achieve broad-spectrum anti-inflammatory effects.
Unlike substances that directly eliminate pathogens or simply enhance immune strength, YR-ALA-LYS-SER-GLN-GLY-GLY-SER-ASN is more like an immune homeostasis regulator. It can not only curb excessive inflammatory responses but also does not weaken the normal defense ability of the body, helping the immune system maintain a balanced state.
What are the breakthrough discoveries of Thymic serum factor in the fields of anti-aging and tumor treatment in recent years?
In recent years, the research direction of Thymic serum factor has no longer been confined to the field of basic immune regulation. Instead, it has focused more on its core role in inflammatory aging and tumor immune regulation, opening up a brand-new research direction for the intervention and repair of various aging-related issues.
One of the significant breakthroughs in the research field has confirmed that Thymulin is a key core mediator linking thymic aging, systemic chronic inflammation, and tumor progression. As the human body ages, the function of the thymus gradually declines and its volume shrinks, and the content of Thymic serum factor in the body continuously decreases. The original inhibitory regulatory effect on myeloid cells also disappears. A large number of activated myeloid cells continuously secrete pro-inflammatory factors such as IL-1α and IL-6, inducing a persistent low-level chronic inflammation, which is known in the industry as inflammatory aging. This long-term imbalance of the inflammatory microenvironment not only accelerates the aging of the body, promotes abnormal cell proliferation, but also directly weakens the body's own immune defense efficiency, leading to the failure of the immune regulatory mechanism.
More importantly, this research conclusion has been translated into effective intervention solutions. Multiple model studies have confirmed that exogenous supplementation of Thymic serum factor can effectively improve the chronic inflammatory imbalance caused by aging. On the one hand, it can effectively inhibit the excessive release of various pro-inflammatory factors, alleviate the inflammatory stress state of the body; on the other hand, it can optimize the immune function of T cells, strengthen the body's ability to recognize and eliminate abnormal cells, and delay the development of lesions. At the same time, it can also reshape the immune response system of the elderly body, improve immune tolerance and product resistance problems, re-activate the immune regulatory activity of the body, and significantly improve the immune defense efficiency of the body.
Based on these unique advantages, Thymic serum factor has now become a highly potential core active ingredient for optimizing the immune state of the elderly body and improving the immune regulatory ability.
MF of Thymic serum factor
| CAS | 63958-90-7 |
| Molecular formula | C33H54N12O15 |
| Molecular weight | 858.85 |
| EINECS | 236-855-3 |
| Boiling point | 1658.9±65.0 °C |
Specification
| Item | Specification | Result |
| Appearance | white powder | Complies |
| Identification(HPLC) | Retention time of sample matches reference standard | Complies |
| Assay | ≥99.0% | 99.60% |
| Related Substances | Any Individual Impuritys ≤ 0.1% Total Impuritiess ≤ 1.0% |
0.03% 0.35% |
| Loss on Drying | ≤0.5% | 0.20% |
| Residue on Ignition | ≤0.1% | 0.04% |
| Heawy Metals | Lead (Pb) ≤ 2.0 ppm Cadmium (Cd) ≤ 1.0 ppm Mercury (Hg) ≤ 1.5 ppm Total Heavy Metals ≤ 10 ppm |
Complies |
| Microbial Limits | Total Plate Count <1000cfu/g Yeast & Moulds <100cfu/g E.Coli Negative Salmonella Negative |
<100 cfu/g <10 cfu/g Negative Negative |
| Conclusion | Conform with enterprise specification | |
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| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Thymulin etc. at a more favorable price. If you are interested, please leave a message.
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FAQ:
Q1:How does thymic serum factor achieve broad-spectrum anti-inflammatory effects?
It can specifically inhibit core inflammatory signaling pathways such as NF-κB and p38 MAPK, thereby reducing the excessive release of various pro-inflammatory factors like IL-1α and IL-6 at their source, and alleviating persistent low-level inflammation in the body. This achieves multi-pathway and broad-spectrum inflammatory regulation effects.
Q2:Will thymic serum factor excessively suppress normal immune defense?
No. It does not contain immunosuppressive components. It only regulates abnormal hyperactive inflammatory pathways and has no negative impact on the body's normal basic immune response and defense mechanisms. It can achieve anti-inflammatory effects while maintaining complete immune protection capabilities.
Q3:Does pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn have any irritancy or safety risks?
As an endogenous active nine-peptide derived from the human body, it has a structure that is compatible with the human body. Within the normal formulation addition range, it is gentle and stable, with extremely low allergenicity and no obvious irritation. It is suitable for the development of long-term care products.
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