What is Terlipressin Acetate?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Terlipressin Acetate, CAS No. 14636-12-5, is a synthetic cyclic polypeptide compound. The free base of this substance has the molecular formula C52H74N16O15S2. The acetate salt binds to an indefinite number of acetic acid molecules. The free base has a molecular weight of 1227.38. The molecule contains disulfide bonds formed by cysteine residues and has a well-defined and fixed amino acid sequence. It appears as a white to off-white powder and is highly soluble in water. This polypeptide can undergo structural transformation in vivo to generate corresponding active polypeptide components, which can act on relevant receptor sites in the body and participate in the regulation of physiological processes related to vascular and visceral circulation.
Application of Terlipressin Acetate
Terlipressin Acetate (CAS 14636-12-5) is a research raw material for peptides related to vasopressin receptor function, widely used in molecular biology and physiological mechanism research. This substance can be used as a tool compound to conduct in vitro experiments on receptor binding characteristics and cellular physiological responses. It can also be applied to various animal models to explore changes in visceral circulation, organ blood flow regulation, and related cellular stress responses. Simultaneously, it is used as an analytical control sample, serving the construction, validation, and quality control of peptide detection methods, providing a reference standard for the development and component identification of peptide-related raw materials.
COA
| Test Item | Specification | Test Result |
| Appearance | White to Off-white Powder | Complies |
| Purity(HPLC) | ≥98.0% | 98.65% |
| Single Maximum Impurity | ≤0.5% | 0.21% |
| Total Impurities | ≤2.0% | 1.08% |
| Water Content | ≤8.0% | 5.32% |
| Acetate Content | Complies with Standard Salt Ratio |
Complies |
| Endotoxin | ≤10 EU/mg | 6.8 EU/mg |
| Conclusion | Conform with enterprise specification | |
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Density 1.46±0.1 g/cm3 (Predicted)
Boiling Point 1824.0±65.0 °C (Predicted)
Molecular Formula C52H74N16O15S2
Molecular Weight 1227.38
Flash Point 1056.9±34.3 °C
Exact Mass 1226.496094
PSA 563.45000
LogP -6.75
InChIKey BENFXAYNYRLAIU-ITQMCZIINA-N
Mechanism of action of Terlipressin acetate
1. Terlipressin Acetate is a polypeptide precursor whose terminal glycine residue is cleaved under biological conditions to generate active lysine vasopressin.
2. The active metabolite derived from terlipressin acetate selectively binds to the V1 subtype receptor, triggering a physiological response in vascular smooth muscle.
3. The activated receptor pathway regulates vascular tone and redistributes blood flow to visceral tissues.
4. This active metabolite alters blood perfusion levels in visceral circulation areas, regulating microcirculation.
5. Terlipressin acetate is cleared more slowly than endogenous polypeptides, allowing it to maintain its effect for a longer duration in experimental systems.
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| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
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| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What type of substance is terlipressin acetate?
Terlipressin Acetate is a synthetically produced cyclic polypeptide compound, belonging to the vasopressin-related precursors, and is a commonly used polypeptide raw material in biological research.
02. What are the standard storage requirements for terlipressin acetate?
The raw material should be stored sealed and protected from light at -20°C. For short-term storage, it can be stored at 2-8°C.
03. What are the characteristics of terlipressin acetate compared to endogenous polypeptides?
This substance has a slower metabolic rate, a longer duration of action, and relatively stable properties, making it more suitable for various long-acting biological experimental studies.
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