What is Abaloparatide?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Abaloparatide, CAS No. 247062-33-5, is a synthetic polypeptide containing 34 amino acid residues, with the molecular formula C₁₇₄H₃₀₀N₅₆O₄₉ and a molecular weight of 3960.5896. It appears as a uniform white powder. This polypeptide selectively binds to the PTH1 receptor and is a crucial experimental material in basic research on bone metabolism, frequently used to explore cell mechanisms and tissue models. The product is prepared using a mature solid-phase polypeptide synthesis route and subsequently undergoes multiplex purification by liquid chromatography. The standard research-grade purity consistently reaches over 98%, with higher grades available to meet the needs of more sophisticated experiments. Long-term storage requires sealing at -20°C, avoiding light, moisture, and temperature fluctuations to minimize the risk of polypeptide degradation.
Application of Abaloparatide
Abaloparatide is primarily used in basic biological research. Leveraging its specific binding to the PTH1 receptor, it is widely applied in research related to bone metabolism. This peptide is frequently used to explore cellular mechanisms, observing bone-related cell proliferation, differentiation, and mineralization processes. It is also extensively used in various animal models to study the evolution of bone microstructure and bone tissue remodeling. Furthermore, it is used in receptor signaling pathway comparison experiments to analyze differences in signal transduction after different peptide molecules bind to their targets, allowing researchers to conduct comparative studies on the characteristics of similar peptides.
COA
| Test Item | Specification | Test Result |
| Appearance | White powder | Complies |
| Purity(HPLC) | ≥98.0% | ≥98.0% |
| Molecular Weight | 3960.59 Da | Consistent |
| Solubility | Soluble in water | Complies |
| Water Content | ≤8.0% | Complies |
| Conclusion | Conform with enterprise specification | |
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Mandibular hypoplasia is a common skeletal deformity in orthodontics. However, the efficacy of functional orthodontic intervention for mandibular development during the growth period is currently limited. The mandibular condyle is one of the main growth areas, and its growth is influenced by various local and systemic factors and mechanical stimuli. Abaloparatide, a parathyroid hormone receptor agonist, has a longer half-life and better stability, thus showing greater application potential.
Mechanism of action of Abaloparatide
This molecule can selectively recognize and bind to a specific conformation of the PTH1 receptor on the cell membrane, distinguishing it from other peptides in the same pathway and inducing a unique receptor activation pattern.
Upon binding to the target, it initiates multiple intracellular signaling pathways, regulating the proliferation, differentiation, and functional activities of bone-related cells, and participating in studies of bone tissue remodeling.
In short-term, intermittent modes of action, it can regulate the balance between two types of bone cells with opposite functions, facilitating the investigation of regulatory mechanisms related to bone matrix formation.
By modifying its structure with specific amino acid sequences, it can prolong receptor activation duration and alter signal response characteristics, becoming an important tool molecule for studying PTH1 receptor conformational preferences.
It is often used in comparative experiments to distinguish differences in downstream signaling pathways when different peptides act on the same target, supporting research on peptide molecular structure optimization.
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Package
Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What synthesis process is used for abaloparatide?
The mainstream preparation method is solid-phase peptide synthesis combined with multi-stage purification using liquid chromatography.
02. In which research areas is abaloparatide mainly used?
It is primarily used in bone metabolism-related research, conducting cell experiments, animal model studies, and comparative structure-activity relationships of peptides.
03. What are the characteristics of abaloparatide's mechanism of action?
Abaloparatide can induce a unique activated form of the PTH1 receptor, regulating bone-related cell activity, making it suitable for comparing signal transduction differences among similar peptides.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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