Hexapeptide-11 Introduction
Hexapeptide-11 was originally extracted by researchers from the fermentation products of baker's yeast. The majority of the raw materials available on the market now follow the solid-phase synthesis route, which offers greater control over purity and batch stability. Its molecular formula is C36H48N6O7, with a molecular weight of 676.8.
As a skin conditioning agent used in cosmetic formulations, Hexapeptide-11 Acetate is commonly found in anti-wrinkle serums and mature skin creams, which are of the "stay-in-place" type. The addition amount of commercial complexes is generally between 0.5% and 3%.
The effect of Hexapeptide-11 is focused on maintaining the cells. In vitro experiments have shown that Hexapeptide-11 can help fibroblasts resist oxidative stress, delay cell aging by regulating the expression of ATM and p53-related proteins, and promote the production of collagen and elastin, thereby achieving visible improvements in skin firmness and elasticity.
Why is Hexapeptide-11 associated with "yeast"?
Many promotional materials tend to link Hexapeptide-11 with yeast. Firstly, this peptide was originally discovered in the yeast system. Secondly, yeast-based skincare ingredients are highly recognized in the industry, and combining them for explanation makes it easier to create a natural product story. However, from a chemical perspective, Hexapeptide-11 Acetate is an artificially synthesized hexapeptide; yeast is only the source where it was initially discovered, and it is not the current production raw material.
What functions does Hexapeptide-11 mainly have in skincare? How is it different from ingredients like Pro-xylane and Vitamin A?
The localization of Hexapeptide-11 Acetate is more focused on "cellular-level maintenance". Public in vitro studies have shown that it can reversibly down-regulate the expression of the two proteins, ATM and p53, thereby helping fibroblasts cope with oxidative stress and delaying the cells from entering the senescence state. In other words, Hexapeptide-11 is concerned with making the skin cells "age more slowly", rather than directly accelerating the epidermal renewal like Vitamin A, or stimulating the synthesis of glycosaminoglycans like Pro-xylane.
MF of Hexapeptide-11
| CAS | 161258-30-6 |
| Molecular formula | C36H48N6O7 |
| EINECS | 000-000-0 |
| Molecular weight | 676.8 |
| Boiling point | 1035.1±65.0 °C |
| Density | 1.269±0.06 g/cm3 |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Assay | ≥96.0% | 99.12% |
| Conclusion | Conform with enterprise specification | |
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FAQ:
Q1:What are the differences between Hexapeptide-11 and Argireline?
The latter is focused on dynamic patterns. Hexapeptide-11, on the other hand, is concerned with the "state maintenance" of fibroblasts themselves.
Q2:What does Hexapeptide-11 do at the cellular level?
According to in vitro studies, it can activate the expression of genes related to the proteasome, autophagy and molecular chaperones, while increasing the level of Nrf2 in the nucleus. In simpler terms, it helps cells remove damaged proteins and enhance their antioxidant defense.
Q3:Does Hexapeptide-11 have an effect on MMP?
Yes. Experiments conducted in vitro have shown that Hexapeptide-11 can induce the activity of extracellular matrix metalloproteinases (MMP).
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