Teriparatide Acetate CAS 52232-67-4

PARATHYROID HORMONE HUMAN: FRAGMENT 1-34 Introduction

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Teriparatide acetate is a recombinant parathyroid hormone, which is used to treat osteoporosis. Studies have shown that Teriparatide is a synthetic 34-peptide, which is a 1-34 amino acid fragment of human parathyroid hormone PTH, and this fragment is the biologically active N- terminal region of endogenous parathyroid hormone PTH containing 84 amino acids. High-purity PTH (1-34) (HUMAN) is white or white-like hygroscopic powder, and its immunological and biological characteristics are completely the same as those of endogenous PTH and bovine PTH(bPTH).

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What is the pharmacological action of Teriparatide acetate?

Teriparatide acetate is a derivative of parathyroid hormone (PTH). It is composed of the 34 amino acid segments with biological activity at the beginning of the PTH molecule. It can specifically bind to the PTH1R receptors on the surface of osteoblasts, osteocytes, and renal tubular cells, thereby initiating subsequent physiological effects.
By using a daily low-dose intermittent contact method, it can achieve the effect of promoting bone synthesis metabolism: it can activate osteoblasts, reduce the apoptosis level of osteoblasts, and assist in the generation of new bone cells, allowing more new bone tissue to be formed between the bone trabeculae and the bone cortex, thereby improving bone mass, bone microstructure, and bone mechanical strength.
In addition, as a PTH receptor agonist, PARATHYROID HORMONE HUMAN: FRAGMENT 1-34 can also participate in the regulation of calcium and phosphorus metabolism in the body, helping the renal tubules increase calcium reabsorption, and at the same time weakening the reabsorption process of phosphorus by the renal tubules.

What are the skincare benefits of Teriparatide acetate?

Human parathyroid hormone-(1-34) is often called eye peptide, which is composed of four amino acids. Its unique structure not only provides some unique skin care characteristics for Teriparatide acetate powder. But also can synthesize a mild and safe colorless and clear liquid bioactive polypeptide. Especially for the repair of sensitive eye areas.
1. Anti-edema and elimination of bags under the eyes: PTH (1-34) (HUMAN) can promote lymphatic drainage, which can alleviate the problems of eye edema and bags under the eyes. It helps to reduce tissue fluid accumulation and improve the appearance of eye area.

2. Anti-inflammatory and anti-oxidation: PTH (HUMAN, 1-34) has anti-inflammatory and anti-oxidation properties, which can reduce the inflammatory reaction of eye skin, resist the damage of free radicals, and help protect eye skin from environmental pollution and oxidative stress.

3. Moisturizing and calming: Teriparatide acetate has moisturizing and calming effects, which helps to relieve eye skin. It can increase the moisture content of skin, reduce skin sensitivity, and make eye skin softer, smoother and more comfortable.

4. Anti-aging: Teriparatide is considered to have a certain anti-aging effect, which can reduce the appearance of skin relaxation, fine lines and wrinkles. It promotes the production of collagen and elastin, and improves the firmness and elasticity of skin.

high purity Teriparatide is often used as an active ingredient in cosmetics and skin care products, but it should be noted that the specific product formula and usage may be different. It is recommended to read and follow the product description and recommended dosage carefully before use.

What is the market prospect of Teriparatide acetate?

hot-sale Teriparatide is the only drug approved by FDA to promote bone growth at present, which is different from the products that inhibit bone absorption and promote calcium absorption. Teriparatide acetate powder is mainly used for patients with severe osteoporosis, patients with fracture tendency or already fractured, and more accurately, it is the last drug used by osteoporosis patients when the products that promote calcium absorption and inhibit bone absorption are ineffective. Therefore, there is no competition in the field of patients with severe osteoporosis. When patients face serious diseases such as fractures caused by osteoporosis, they either don't treat them, and other drugs are useless, or they choose teriparatide, and there is no other choice.

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FAQ:

Q1:Does teriparatide acetate have a direct promoting effect on fracture healing?

There is evidence suggesting that it can accelerate fracture healing. A randomized controlled trial conducted on patients after intertrochanteric femoral fractures found that daily use of Teriparatide treatment for 12 weeks after surgery resulted in an average reduction of approximately 3.12 weeks in the radiological healing time of the bone.
Q2:How exactly does it work at the cellular level?

Teriparatide acetate exerts its effect by specifically binding to and activating the parathyroid hormone type 1 receptor (PTH1R) on the surface of osteoblasts and bone matrix cells. This binding initiates intracellular signaling pathways such as cAMP, thereby promoting the differentiation, proliferation of osteoblasts, and inhibiting their apoptosis, ultimately achieving a net increase in bone mass.

Q3:Why do patients stop their treatment? What are the main side effects?

In that real-world study as well, the main reason for the discontinuation was adverse events (48 cases), followed by fear of self-administration, insufficient efficacy, etc. The most common side effects included nausea, vomiting or abdominal discomfort, as well as palpitations, low blood pressure, headache and dizziness.

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