What is Cagrilintide peptide?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Cagrilintide peptide is a structurally modified synthetic polypeptide, CAS number 1415456-99-3. This molecule belongs to the acylated amylin analogue group, with a total of 38 amino acids in its peptide chain. It contains a single disulfide bond forming a cyclic spatial structure. A C20 fatty acid diacid group is introduced at the N-terminus, which, through its binding properties to albumin, significantly extends the molecule's retention time in biological systems. It appears as a white powder with good water solubility, and its purity can reach 98-99% using conventional HPLC.
Application of Cagrilintide peptide
Cagrilintide peptide (CAS 1415456-99-3), as a research peptide raw material for long-acting acylated amylin analogues, is mainly used for laboratory research in metabolism-related fields. It can be used to explore the signaling pathway mechanisms related to amylin receptor and calcitonin receptor, and to conduct model experiments related to energy balance, food signal transduction, and changes in body composition. It is also often used to explore the combinatorial effects between peptide molecules, compare the differences in metabolism-related responses under different peptide systems, help researchers understand the regulatory logic of endogenous hormones, and provide experimental materials for peptide molecular structure optimization and target action mechanism analysis.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white powder | White powder |
| Solubility | Freely soluble in pure water | Complies |
| Purity(HPLC) | ≥98.0% | 99.25% |
| Maximum Single Impurity | ≤2.0% | 0.41% |
| Molecular Weight(LC-MS) | 4409.01±1.0 Da | Consistent with theoretical value |
| Moisture Content | ≤5.0% | 2.08% |
| Amino Acid Composition | Within±15%of theoretical value |
Complies |
| Endotoxin Content | <5 EU/mg | 2.1 EU/mg |
| Conclusion | Conform with enterprise specification | |
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In in vivo model studies, this peptide is often used in metabolic-related animal models constructed with a high-fat diet to observe the changes brought about by the molecule on indicators such as feeding behavior, body composition, energy homeostasis, and liver lipid accumulation. It also compares the differences in stability and duration of action between natural amylin and the modified molecule, explaining how acylation modification can enhance the duration of action by binding to albumin.
Mechanism of action of Cagrilintide
1. Cagrilintide peptide binds to the amylin receptor and the calcitonin-RAMP receptor complex, initiating downstream signal transduction and achieving dual-target activation.
2. The C20 fatty acid diacid modification group on the molecule can bind to albumin in vivo, slowing down molecule clearance and prolonging the peptide's survival time in the biological environment.
3. Cagrilintide acts on central nervous system signaling pathways, participating in the regulation of food intake-related signal transduction and downregulating signals related to energy intake.
4. This peptide can regulate signals related to energy distribution in the body, intervening in changes in body fat composition, with relatively limited impact on lean body mass-related signals.
5. When Cagrilintide coexists with other peptide molecules, the two signaling pathways can produce a synergistic effect, amplifying the response performance in metabolic models.
6. The modified peptide chain structure reduces the tendency of natural amylin to aggregate, improves molecular stability, and reduces interference from non-specific aggregation.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
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| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What is the role of the C20 fatty acid diacid group on the Cagrilintide molecule?
This group can bind to albumin, slowing down the molecule's clearance rate and prolonging its survival time in biological systems.
02. What special structure exists within the Cagrilintide molecule?
The peptide chain contains a pair of disulfide bonds, enabling it to form a specific cyclic spatial conformation.
03. What are the advantages of Cagrilintide compared to natural amylin?
Cagrilintide peptide chain undergoes amino acid modification to reduce its tendency to aggregate, while acylation significantly enhances its stability.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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