Astressin-B
Product Name:astressin B
Synonym:Astressin-B
CAS NO.:/
EINECS NO.:/
Molecular Formula:/
Purity & Grade: 99%; Medicine grade
Character:White powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 5-10 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description
Astressin-B is a non-selective corticotropin-releasing factor (CRF) receptor antagonist, belonging to the Astressin family of synthetic peptide compounds, and has important applications in neuroendocrinology, stress research, and dermatology.
Bioactivity and Mechanism of Action
Receptor Binding Characteristics
Non-selective CRF₁/CRF₂ receptor antagonist with high affinity for both receptor subtypes
Dose-dependent blockade of ACTH and cortisol responses stimulated by CRH, with effects lasting over 24 hours.
Main Physiological Effects
Reduces adrenocorticotropic hormone (ACTH) and cortisol synthesis, inhibiting hypothalamic-pituitary-adrenal (HPA) axis activity.
Improves sexual drive in rats under stress.
Delays emptying of solid food in mice.
Prevents ACTH release induced by shock, alcohol, and endotoxemia.
Reverses and prevents alopecia areata (patchy hair loss) in CRF-overexpressing mice, inducing pigmentation and hair regrowth.
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COA
| Tests | Specifications | Results |
| Appearance | White or almost white fluffy powder | Conform |
| Solubility | Soluble in water and acetic acid | Conform |
| Water Content(Karl Fischer) | ≤8.0% | 4.00% |
| Acetic Acid (By RPLC) | < 15.0% | 2.00% |
| Peptide Purity (By RPLC) |
> 98. 0% | 99.20% |
| Related Substance(By HPLC) | Total Impurities ≤2.0% | 0.80% |
| Largest Single Impurity≤1.0% | 0.60% | |
| Organic Solvent Residue | Acetonitrile ≤ 0.041% | < 0.041% |
| Dichloromethane ≤ 0.060% | < 0.060% | |
| N,N-Dimethylformamide ≤ 0.088% | < 0.088% | |
| Conclusion | Conform with enterprise specification | |
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Potential for Treating Hair Loss
A significant 2011 study found that Astressin-B significantly promoted hair regrowth in mice under prolonged stress and experiencing hair loss. This effect was remarkably long-lasting.
This finding suggests that blocking peripheral CRH receptors may be a key mechanism for "resetting" hair growth in stress-related alopecia. Researchers at UCLA and the Salk Institute have filed patent applications for the peptide's potential in promoting hair growth. However, it's important to note that these studies are all animal-based, and further research is needed to determine its efficacy and safety in humans.
Application research areas of Astressin-B
Neuroendocrine research:
Used to study the role of CRF receptors in stress response.
Assessing the relationship between HPA axis dysfunction and mental illnesses (anxiety, depression).
Dermatological applications:
Hair regeneration: Improves the hair follicle microenvironment by modulating stress hormone receptors, promoting hair and eyelash growth.
Treatment of autoimmune alopecia: Shows significant efficacy in a CRF overexpression mouse model.
Reproductive endocrinology: Prevents the inhibitory effect of ghrelin on luteinizing hormone (LH) pulse frequency in ovariectomized rhesus monkeys.
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why choose us
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. What are the core chemical structural features of Astressin-B?
02. What is the affinity of Astressin-B for CRF receptors?
It has high affinity for both receptor subtypes. In in vitro experiments, its IC₅₀ values are approximately 2 nM for CRF₁ receptors and approximately 1.5 nM for CRF₂ receptors, classifying it as a potent, non-selective CRF receptor antagonist.
03. Where can I buy Astressin-B?
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