Vortioxetine Hydrobromide Raw Powder CAS 960203-27-4

Vortioxetine hydrobromide Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.

As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.

Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.

Vortioxetine is a low molecular weight piperazine sulfide, and it is also a new type of diaryl sulfanilamide antidepressant product, which is used to treat depression and anxiety. In vitro studies show that it can antagonize 5-HT3, 5-HT7 and 5-HT1D receptors, activate 5-HT1A receptors, partially activate 5-HT1B receptors and inhibit 5-HT transport. High-quality votexetine powder is a white to white-like solid, and vortioxetine hydrobromide raw powder made of it is a slightly yellowish white powder, which is slightly soluble in water.The core application is for the treatment of severe depression in adults. Besides, it also shows considerable potential for development in treating depression in children and adolescents, as well as in addressing somatic symptom disorders or improving cognitive functions.

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What are the pharmacological effects of  Vortioxetine hydrobromide?

The action pathways of vortioxetine hydrobromide are complex, and the current research has not yet fully clarified all the principles. The mainstream view in the industry holds that it can produce an emotional soothing effect, mainly relying on its special mode of multi-targeted coordinated regulation of the 5-Hydroxytryptamine pathway.
The most basic action path of this substance is to block the 5-Hydroxytryptamine transporter, reducing the amount of 5-Hydroxytryptamine reabsorbed in the synaptic cleft, thereby increasing the overall content of 5-Hydroxytryptamine in the brain and enhancing the activity of this signaling molecule. In addition, it can directly bind and regulate multiple 5-Hydroxytryptamine subtype receptors: activating the 5-HT1A receptor, partially activating the 5-HT1B receptor, and blocking the signal transduction of 5-HT3, 5-HT7, and 5-HT1D receptors.
The existing experimental data indicate that this multi-targeted synchronous regulation characteristic will indirectly influence various signal transduction systems related to emotional perception in the brain, including DL -METANEPHRINE, 3-Hydroxytyramine, Acetylcholine, etc. This special action feature is also regarded by the academic community as the key reason why Vortioxetine Hydrobromide Raw Powder can simultaneously optimize emotional states, cognitive performance, and have differentiated side effects.

How about the clinical application of Vortioxetine hydrobromide?

1. Vortioxetine hydrobromide raw powder has high affinity with 5-HT receptor. Compared with duloxetine, Vortioxetine can selectively act on 5-HT3, 5-HT1A, 5-HT7, 5-HT1D and 5-HT1B receptors, which can regulate mood and improve patients' compliance.
2. As a new antidepressant, VORTIOXETINE HBR is considered to be the most successful product in the study of unipolar affective disorder. The results show that compared with placebo, LU AA21004 HBR is effective in antidepressant, which can greatly increase the rate of 5-HTT, and the incidence of adverse reactions is lower than that of venlafaxine and duloxetine. Another clinical study shows that LU AA 21004 HYDROBROMIDE can effectively reduce the possibility of recurrence of patients after treatment.
3. Animal experiments show that the behavioral analysis and prediction of the antidepressant activity of Voetixetine has a significant effect. In several rat anti-anxiety models, compared with other known antidepressants, the anti-anxiety activity of Vortioxetine hcl is higher, especially for the anxiety state that Paroxetine and Duloxetine are ineffective, and it still has anti-anxiety effect, with obvious clinical advantages.
4. The most common side effect of Lu AA 21004 hydrobromide is nausea, but it is usually mild or moderate, which appears in the first two weeks of treatment and is usually a one-time reaction. Other common adverse reactions include abnormal dreams, dizziness, diarrhea, constipation, vomiting and itching, and occasional flushing and night sweats.

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FAQ:

Q1:What are the common side effects of vortioxetine hydrobromide?
The most common side effect is nausea. This nausea is usually mild to moderate and occurs within the first two weeks of treatment, and most of it will subside on its own as the treatment continues. Other common side effects include vomiting, constipation, dizziness, and abnormal dreams.
Q2:Is Vortioxetine hydrobromide good for sleep?
Accordingly, VOR improved subjective sleep efficiency and continuity without affecting daytime functioning and diurnal alertness. Consistently, daytime sleepiness improved during VOR treatment.
Q3:Should I take Vortioxetine hydrobromide at night or day?

It is recommended to take the medicine at a fixed time every day. It can be taken with or after meals.If taken once a day, it is usually best to take it during breakfast, as taking it at night may affect sleep.

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