Entacapone Powder CAS 130929-57-6

Entacapone powder is a white to light brown anti Parkinson's disease product. Pure OR611 is a highly selective and potent catechol oxymethyltransferase (COMT) inhibitor that mainly acts in the intestine and rarely penetrates the blood-brain fluid barrier, making it much safer than other products.

Why is it an adjuvant drug for Parkinson's disease?

OR-611 powder is a very good COMT inhibitor, which plays a role by inhibiting the conversion and metabolism of levodopa. However, levodopa in Parkinson's patients is often insufficient. Clinical studies have found that proper dosage can reduce the levels of 3-OMD in serum and brain, increase the levels of levodopa, dopamine and DOPAC in brain and significantly reduce the dosage required to increase the dopamine concentration in striatum. The combination of levodopa and carbidopa with COMTI can significantly increase the bioavailability of levodopa (3 ~ 4 times). Therefore, this dependence has laid the auxiliary role of this product. In addition, the bioavailability of this product is very dependent on the dose, ranging from 5 to 5～800 mg. Excessive use will be very dangerous, such as abnormal reactions of the central nervous system, hallucinations, delirium and other reactions. Therefore, it is very unwise and uneconomical to use this product as the main product to improve the body's own levodopa (instead of using it with levodopa and other products).

Clinical application notes:

1: Not recommended for use during pregnancy; Entacapone raw material can be excreted through breast milk, but its safety for infants is still unclear. Therefore, breastfeeding should be stopped when using this medicine.
2: This product can turn urine reddish brown, but this phenomenon is harmless.
3: The combination of Entacapone and levodopa can cause dizziness, orthostatic hypotension, and inability to drive and operate machines after medication.
4: Sudden cessation or reduction of medication may lead to symptoms and signs of Parkinson's disease, as well as symptoms similar to malignant syndrome (NMS), accompanied by high fever and mental disorders. So slow discontinuation of medication is necessary. If symptoms and signs still appear, the dose of levodopa needs to be increased.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Entacapone powder etc. at a more favorable price. If you are interested, please leave a message.

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