Citalopram Hydrobromide Weight Loss CAS 59729-32-7

Citalopram hydrobromide weight loss is a white solid powder at normal temperature and pressure. Citalopram HBr is a selective serotonin reuptake inhibitor (SSRI) antidepressant, which has been approved by FDA for the treatment of depression. Clinically, it is mainly used to treat depressive mental disorders (endogenous and endogenous depression). It should be pointed out that this product is a primary version. Later, Escitalopram Oxalate 219861-08-2, which is more effective and safer, was developed. It is known as the purest serotonin reuptake agent. Because of its less side effects, faster onset and safer price, it is the first choice for many doctors at present. In addition, Citalopram HBr can also be used as an intermediate in organic synthesis and medicinal chemistry, and can be used for the preparation and modification of drug molecules and bioactive molecules.

What's the difference between Citalopram Hydrobromide Weight Loss and Escitalopram oxalate?

However, due to the essential differences in their chemical structures, their reaction processes are different. Details are as follows:

1 acid radical difference

When purchasing, we will notice that many product names are preceded by hydrochloric acid, sulfuric acid, succinic acid, tartaric acid, etc. These symbols are usually called acid radicals, such as "hydrobromic acid" and "oxalic acid" in "Citalopram hydrobromide" and "Escitalopram oxalate" mentioned here. Acid radical is not the main effective component of the drug, but is artificially added to change the physical and chemical properties of the drug, such as solubility, partition coefficient, dissociation degree, etc., and the pharmacodynamic groups are made into organic salts or inorganic salts, which is beneficial to the stability of the drug and makes the drug easier to absorb. It's like citalopram hydrobromide is more easily absorbed by the body than Escitalopram oxalate.

2 structural differences

Citalopram is a raceme, which consists of two stereoisomers, one of which is S- citalopram and the other is R- citalopram, each of which accounts for 50%, and they are mirror images of each other, just like human hands. Although they look the same, they cannot overlap. Escitalopram oxalate is a single S- isomer after removing the R conformation. Lu 10-171 HBr is a complete product that has not been eliminated. Therefore, citalopram hydrobromide weight loss will be better absorbed by the body, but its effectiveness will be weaker.

3 in vivo process

As mentioned earlier, both S and R molecules do not work well in the body. Small R doesn't match the drug binding site in vivo, so it can't effectively combine, so it can't effectively exert its antidepressant activity. However, the R structure of Citalopram hydrobromide can perfectly combine with hydrobromic acid, making the finished product not easy to disintegrate, but it is easy to separate and dissolve in water and be absorbed by the body. Escitalopram oxalate removes 50% of the R configuration that affects antidepressant activity in citalopram, so that the antidepressant component reaches 100%.

4 dosage difference

It is precisely because of their different emphases that Escitalopram oxalate is used less every day, but the effect is good. Can it cope with sudden and serious depression patients? However, the price is higher, which makes Citalopram hydrobromide more close to the people for difficult families. However, because of the large side effects of this product, it needs to be used for a longer time under the same measurement.

What are the advantages of Citalopram Hydrobromide Weight Loss?

a highly selective 5- hydroxytryptamine (5-HT) uptake inhibitor Citalopram Hydrobromide Weight Loss has antidepressant effect. Compared with other antidepressant products such as Escitalopram oxalate, this product has no inhibitory effect on cholinergic muscarinic receptor, histamine receptor and α -adrenergic receptor. Therefore, there will be no side effects caused by many antidepressant products, such as dry mouth, sedation, postural hypotension and so on. Citalopran HBr is equally effective for patients with endogenous and non-endogenous depression, and its antidepressant effect usually takes 2-4 weeks to establish. Citalopran HBr does not affect the cardiac conduction system and blood pressure, which is particularly important for elderly patients, especially those with bradycardia. Its appearance makes the treatment of bradycardia more calm and complicated. In addition, CITALOPRAM HBR does not affect blood, liver and kidney systems. Rare side effects and mild sedation make it especially suitable for long-term treatment. It will not lead to weight gain, nor will it strengthen the role of alcohol.

What are the adverse reactions about Citalopram Hydrobromide Weight Loss?

The adverse reactions of Citalopran are usually few, mild and short-lived. The most common adverse reactions are nausea, increased sweating, decreased salivation, headache and shortened sleep time. It is usually obvious in the first or second week of treatment, and generally disappears gradually with the improvement of depression. Seizures have been observed in rare cases.

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