Pramipexole hydrochloride is a dopamine receptor agonist that mimics the function of dopamine by binding to dopamine receptors in the brain, thereby improving symptoms of Parkinson's disease. In clinical applications, Pramipexole dihydrochloride monohydrate can be used alone or in combination with levodopa. For example, when the efficacy of levodopa gradually weakens or changes and fluctuates in the later stages of the disease, this product is usually needed for auxiliary use. 99% Pramipexole Powder is a white to almost white solid with good solubility in water, which can be used to make various solvents.
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Item |
Standard |
Test Results |
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Appearance |
White powder |
Conforms |
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Identification (IR) |
Concordant with reference spectrum |
Conforms |
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Assay |
≥99.0% |
99.2% |
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Water |
<2.0% |
0.4% |
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Residual solvent |
<1.0% |
0.2% |
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Heavy Metals |
≤15 |
10 |
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Loss on Drying |
≤0.3% |
0.04% |
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Residue on Ignition |
≤0.3% |
0.08% |
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Chromatographic purity |
Meets the requirements |
Conforms |
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Organic volatile impurities |
Meets the requirements |
Conforms |
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Microbial assessment |
Compliance with indicators |
Conforms |
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BSE |
not detected |
not detected |
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GMO |
not detected |
not detected |
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Allergen |
not detected |
not detected |
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Radiation |
not detected |
not detected |
| Conclusion： |
Conform with enterprise specification . |
What are the pharmacological effects of this product?
99% Pramipexole Powder is a non-ergot dopamine receptor agonist, which can improve the symptoms of Parkinson's disease by combining with dopamine receptors in the brain to simulate the function of dopamine. Specifically, Pramipexole dihydrochloride monohydrate mainly acts on D2 subfamily of dopamine receptors, with high selectivity and specificity, especially for D3 receptors, and has complete intrinsic activity. By acting on dopamine receptors in striatum, Good quality Pramipexole Dihydrochloride can inhibit the synthesis, release and renewal of dopamine, protect dopamine neurons from ischemia or neurotoxicity of methylisopropylamine, and neurotoxicity caused by levodopa, thus improving the motor symptoms of patients with Parkinson's disease.
How about the clinical application of this product?
Pramipexole plays an important role in the treatment of Parkinson's disease. It can be used as monotherapy or in combination with other anti-Parkinson's drugs, but the following points should be observed:
1. When combined with inhibitors of renal clearance pathway or drugs cleared by this pathway, the content of pramipexole hydrochloride should be reduced.
2. When combined with levodopa, it is suggested to reduce the content of levodopa when increasing the content of 99% Pramipexole Powder, if the dosage of other anti-Parkinson products can remain unchanged.
3. Patients should not be associated with other sedative products or alcohol when using this product to avoid antagonism.
In clinical use, if the patient is in the early stage of the disease, it can significantly improve the motor symptoms of the patient, such as tremor, bradykinesia and so on. In the middle and late stage of the disease, it can still maintain a certain curative effect to reduce the burden of symptoms of patients. In addition, the rational use of Pramipexole dihydrochloride can also be used to improve the non-motor symptoms of patients with Parkinson's disease, such as sleep disorder and cognitive disorder. Although pramipexole hydrochloride has achieved remarkable results in the treatment of Parkinson's disease, it also has some side effects, especially some serious side effects, which need to be followed up in time.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide 99% Pramipexole Powder etc. at a more favorable price. If you are interested, please leave a message.
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