What is the drug lesinurad used for?
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Lesinurad is used together with a xanthine oxidase inhibitor (eg, allopurinol, febuxostat) to treat gout. It works to lower uric acid levels in the blood.
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https://www.faithful-chemical.com/api-powder/lesinurad-powder-cas-878672-00-5.html
Is lesinurad a uricosuric agent?
Lesinurad is a uricosuric agent in development for the chronic management of gout and hyperuricemia.
What is the classification of Lesinurad?
Lesinurad is a member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout. It has a role as a uricosuric drug.
What class of BCS is Lesinurad?
Lesinurad is a BCS class 2, low solubility drug, indicated for hyperglycemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone.
How does Lesinurad work?
Lesinurad is in a class of medications called selective uric acid reabsorption inhibitors. It works by helping the kidneys to remove uric acid from the body.
Is lesinurad uricosuric?
Lesinurad is a novel uricosuric drug that inhibits the urate transporter proteins URAT1 and OAT4, intended for patients who have not achieved target serum uric acid levels with the use of a xanthine oxidase inhibitor alone.
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The synthesis of lesinurad can generally be obtained by the epoxidation of cyclohexane. Cyclohexane is first reacted with hydrogen peroxide (H2O2). In the presence of an alkaline catalyst, cyclohexane is oxidized to cyclohexane-2, 3-epoxide. The epoxide is then reacted with silver carbonate to obtain the product of lesinurad. The reaction temperature and pH value need to be controlled during the reaction to obtain high yield and purity. The synthesis of lesinurad should be carried out in strict accordance with laboratory operating procedures and ensure safety and environmental friendliness.
MECHANISM
The mechanism of action of lesinurad is mainly by inhibiting the function of transporters involved in uric acid reabsorption in the kidney, helping the kidney to excrete uric acid. It is a uric acid transport inhibitor and is primarily used to treat high blood uric acid levels associated with gout. It can selectively inhibit the function of uric acid transporter 1(URAT1) and organic anion transporter (OAT), thereby reducing the reabsorption of uric acid in the kidney and increasing the excretion of uric acid. This can reduce the level of uric acid in the blood, which can relieve the symptoms of gout. However, lesinurad is often used with drugs such as allopurinol or febuxostat to achieve better treatment results.
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