What does Melanotan 2 do to your body?

Melanotan II is a synthetic analog of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal. which causes pigmentation (tanning) of human skin. Melanotan II is a variant of Melanotan I (afamelanotide), a drug used in the treatment of erythropoietic protoporphyria.

How does Melanotan II work?

Melanotan II acts as a non-selective agonist of the melanocortin receptors MC1, MC3, MC4, and MC5. It affects melanocortin 1, 3, 4, and 5 receptors. It is said to be a small protective amino acid structure design

Melanotan II non-selectively mimics the action of melanocortin peptides. These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like Melanotan I (afamelanotide), Melanotan II produces melanogenesis by activation of the MC1 receptor, causing the skin to go darker (tanning).whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to also possibly be involved).

Side effects of Melanotan II

Short-term side effects after administration include:

Facial flushing

Reduced appetite （the last via activation of MC₄）, nausea, and vomiting

In males, spontaneous erections 1-5 hours after administration (priapism), are associated with yawning and stretching complex

Long term, there is concern that Melanotan II may increase the risk of:

Melanoma – a potentially serious form of skin cancer

Deepening of the color of moles, new moles, and atypical melanocytic naevi

Melanonychia – brown to black discoloration of one or more nails

Rhabdomyolysis – potentially fatal destruction of muscle cells

Encephalopathy syndrome

Market Research and evaluation of this product

Melanotan2 on melanocytes to stimulate melanin production. Melanin is the body’s pigment responsible for a photoprotective safe tan.

Melanotan II binds to melanocortin receptors influencing pigmentation, inflammation, energy, appetite, and sexual function.

Melanotan 2 is a small efficient molecule as compared to the linear original Melanotan I design after natural melanocyte stimulating hormone peptide. Melanotan is approximately 1,000 times more potent than natural a-MSH. Melanotan half-life of minutes, Melanotan 2 half-life ~1 hour.

Folks who never tan, and always burn in the sun, can achieve a natural tan when using Melanotan II. For people with sun allergies/mutated receptors, synthetic melanotropin peptide supplements offer life-changing opportunities. A natural tan developed over time is the best defense against cancer. Melanotan was designed to reduce cancer rates and potentially become effective as a sunless tanning agent. Athletes and fitness enthusiasts use Melanotan for accelerated tanning, libido increase, and appetite suppression.

Melanotan 2 was dubbed the Barbie drug and has been highlighted in wired magazine. Melanotan II continues to be the most effective tanning peptide sold online.

New research and precautions about this product

During clinic trials for its use as a tanning agent, Melanotan II was found to be a potent stimulator of male erections. A new drug based on Melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.

But， Melanotan II is not approved for the treatment of any medical conditions currently and has not been fully tested， It has been reported to cause a wide range of potentially serious side effects. Warnings against its use have been issued from the US, UK, and several other countries.

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