what is N-Acetyl-L-tryptophan?
N-Acetyl-L-tryptophan is a N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan. It has a role as a metabolite. It is a L-tryptophan derivative and a N-acetyl-L-amino acid. It is a conjugate acid of a N-acetyl-L-tryptophanate. It is an enantiomer of a N-acetyl-D-trypsin, a colorless to light yellow crystalline powder that is soluble in water and polar organic solvents.
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Product name |
N-Acetyl-L-tryptophan |
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CAS |
1218-34-4 |
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Molecular formula |
C13H14N2O3 |
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Molecular weight |
246.26 | |
| EINECS | 214-935-9 | |
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Appearance |
white powder |
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| Melting point | 186°C | |
| Desity |
1.1855g/cm3 |
What are the application of N-Acetyl-L-tryptophan?
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1. Pharmaceutical industry: N-acetyl-L-tryptophan is used as a pharmaceutical ingredient, mainly used to treat mental health problems such as sleep disorders, depression and anxiety. It can also be used as an adjuvant to help improve memory and cognitive function. 2. Food industry: In the food industry, N-acetyl-L-tryptophan can be added as a nutritional supplement to beverages, health supplements or specific foods to provide additional amino acid components and support human health. 3. Cosmetics and skin care products: Since tryptophan has antioxidant and anti-inflammatory properties, N-acetyl-L-tryptophan is also used in cosmetics and skin care products to improve skin health, reduce inflammation and promote skin repair. 4. Agriculture and animal health: In the agricultural field, N-acetyl-L-tryptophan can be used as a feed additive and provided to poultry and pets to help improve their growth performance and immune system health. 5. Scientific research: In scientific research, N-acetyl-L-tryptophan is often used as a research substance, especially for understanding the mechanism of tryptophan metabolism pathway, neurotransmitter regulation, and related diseases. |
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What are the biological activities of N-acetyl-L-tryptophan?
N-acetyl-L-tryptophan is an antagonist of the neurokinin receptor (NK-1R) that disrupts the binding of substance P (SP) to NK-1R, exerting neuroprotective effects and improving memory deficits and motor disorders. At the same time, N-acetyl-L-tritophan is also an inhibitor of cytochrome c, which can exert antioxidant and anti-inflammatory effects by inhibiting IL-1 β expression and caspase-1 activation. N-Acetyl-L-tryptophan is expected to be used for research in the fields of neurodegenerative and inflammatory diseases.
Product Specification
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Items |
Specifications |
Results |
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Appearance |
White to off-white powder |
White powder |
| Specific Rotation [a]20/D(c=1 in 1mol/L NaOH) | 24-28(°) |
26(°) |
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NMR |
Consistent with structure |
Conforms |
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Assay |
99.0%~100.5% |
99.6% |
Conclusion：Conform with specification and qualified.
What are the related studies on N-Acetyl-L-tryptophan?
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N-Acetyl-L-tryptophan decreased the levels of alanine aminotransferase (ALT) and aspartate transaminase (AST) in fibrotic mice model induced by carbon tetrachloride (CCl4). Histological staining showed that l-NAT ameliorated liver injury and fibrosis, and reduced the expression of α-smooth muscle actin (α-SMA) and Collagen I protein. l-NAT also attenuated apoptosis by down-regulating the level of pro-apoptotic protein Bax and up-regulating that of anti-apoptotic protein Bcl-2. Moreover, l-NAT inhibited the expressions of TGF-β1/SMAD and matrix metalloproteinase 9 (MMP9) proteins, and reversed the expression of YAP1 protein in CCl4-induced liver fibrosis. |
How to prepare N-Acetyl-L-tryptophan?
The preparation of N-acetyl-L-Tryptophan is usually obtained by reacting L-tryptophan with other compounds. In the specific steps, L-tryptophan is reacted in the presence of an appropriate catalyst under appropriate temperature and reaction time conditions to produce a product, which is then crystallized and purified to obtain the final N-acetyl-L-tritophan.
How and where to buy N-Acetyl-L-tryptophan?
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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